Format

Send to:

Choose Destination

UBE2R2 ubiquitin conjugating enzyme E2 R2 [ Homo sapiens (human) ]

Gene ID: 54926, updated on 24-Nov-2020

Summary

Official Symbol
UBE2R2provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 R2provided by HGNC
Primary source
HGNC:HGNC:19907
See related
Ensembl:ENSG00000107341 MIM:612506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBC3B; CDC34B; E2-CDC34B
Summary
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 25.6), endometrium (RPKM 16.9) and 25 other tissues See more
Orthologs

Genomic context

See UBE2R2 in Genome Data Viewer
Location:
9p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (33817160..33920399)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33817162..33920401)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1251 Neighboring gene serine protease 3 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene RNA, U4atac small nuclear 11, pseudogene Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene ubiquitin associated protein 2 Neighboring gene small nucleolar RNA, C/D box 121A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20419, MGC10481

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 R2
Names
E2 ubiquitin-conjugating enzyme R2
ubiquitin carrier protein R2
ubiquitin conjugating enzyme E2R 2
ubiquitin-conjugating enzyme E2-CDC34B
ubiquitin-conjugating enzyme UBC3B
ubiquitin-protein ligase R2
NP_060281.2
XP_005251553.1
XP_011516251.1
XP_016870349.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017811.4NP_060281.2  ubiquitin-conjugating enzyme E2 R2

    See identical proteins and their annotated locations for NP_060281.2

    Status: REVIEWED

    Source sequence(s)
    AA397839, AK000426, AL133827, AL139113, AW966809, BC004862, BC047584, BI061548, BI908167, BQ432410, CD515389, CN310827, CN427315
    Consensus CDS
    CCDS6546.1
    UniProtKB/Swiss-Prot
    Q712K3
    Related
    ENSP00000263228.3, ENST00000263228.4
    Conserved Domains (1) summary
    cd00195
    Location:11169
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    33817160..33920399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517949.1XP_011516251.1  ubiquitin-conjugating enzyme E2 R2 isoform X2

    See identical proteins and their annotated locations for XP_011516251.1

    Conserved Domains (1) summary
    cd00195
    Location:11122
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_005251496.2XP_005251553.1  ubiquitin-conjugating enzyme E2 R2 isoform X1

    See identical proteins and their annotated locations for XP_005251553.1

    Conserved Domains (1) summary
    cd00195
    Location:11140
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. XM_017014860.1XP_016870349.1  ubiquitin-conjugating enzyme E2 R2 isoform X3

Support Center