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CHTF8 chromosome transmission fidelity factor 8 [ Homo sapiens (human) ]

Gene ID: 54921, updated on 5-Apr-2020

Summary

Official Symbol
CHTF8provided by HGNC
Official Full Name
chromosome transmission fidelity factor 8provided by HGNC
Primary source
HGNC:HGNC:24353
See related
Ensembl:ENSG00000168802 MIM:613202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTF8; DERPC
Summary
This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. [provided by RefSeq, Oct 2018]
Expression
Ubiquitous expression in thyroid (RPKM 29.7), kidney (RPKM 27.6) and 25 other tissues See more
Orthologs

Genomic context

See CHTF8 in Genome Data Viewer
Location:
16q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (69118010..69132588, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69151912..69166493, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 6 homolog Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like Neighboring gene ribosomal protein S2 pseudogene 45 Neighboring gene hyaluronan synthase 3 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene Sharpr-MPRA regulatory region 12307 Neighboring gene UTP4 small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20400

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Ctf18 RFC-like complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chromosome transmission fidelity protein 8 homolog
Names
CTF8, chromosome transmission fidelity factor 8 homolog
decreased expression in renal and prostate cancer protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039690.5NP_001034779.1  chromosome transmission fidelity protein 8 homolog

    See identical proteins and their annotated locations for NP_001034779.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC009027
    Consensus CDS
    CCDS42185.1
    UniProtKB/Swiss-Prot
    P0CG13
    Related
    ENSP00000408367.2, ENST00000448552.6
    Conserved Domains (1) summary
    pfam09696
    Location:13113
    Ctf8; Ctf8
  2. NM_001040146.5NP_001035236.1  chromosome transmission fidelity protein 8 homolog

    See identical proteins and their annotated locations for NP_001035236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC009027
    Consensus CDS
    CCDS42185.1
    UniProtKB/Swiss-Prot
    P0CG13
    Related
    ENSP00000381290.2, ENST00000398235.6
    Conserved Domains (1) summary
    pfam09696
    Location:13113
    Ctf8; Ctf8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    69118010..69132588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040145.1: Suppressed sequence

    Description
    NM_001040145.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
  2. NM_017804.3: Suppressed sequence

    Description
    NM_017804.3: This RefSeq was permanently suppressed because the protein coding region was erroneously annotated in the 3' UTR and represented an invalid protein (NP_060274.3).
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