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RETSAT retinol saturase [ Homo sapiens (human) ]

Gene ID: 54884, updated on 5-Jun-2022

Summary

Official Symbol
RETSATprovided by HGNC
Official Full Name
retinol saturaseprovided by HGNC
Primary source
HGNC:HGNC:25991
See related
Ensembl:ENSG00000042445 MIM:617597; AllianceGenome:HGNC:25991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable all-trans-retinol 13,14-reductase activity. Predicted to be involved in retinol metabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 182.7), duodenum (RPKM 78.0) and 17 other tissues See more
Orthologs
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Genomic context

See RETSAT in Genome Data Viewer
Location:
2p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85341955..85354528, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85343946..85356519, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85569078..85581651, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene trans-golgi network protein 2 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 2 Neighboring gene ELMO domain containing 3 Neighboring gene RNA, 7SL, cytoplasmic 113, pseudogene Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables all-trans-retinol 13,14-reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables all-trans-retinol 13,14-reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retinol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nuclear outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
all-trans-retinol 13,14-reductase
Names
PPAR-alpha-regulated and starvation-induced gene protein
all-trans-13,14-dihydroretinol saturase
NP_060220.3
XP_047300784.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017750.4NP_060220.3  all-trans-retinol 13,14-reductase precursor

    See identical proteins and their annotated locations for NP_060220.3

    Status: VALIDATED

    Source sequence(s)
    AK075261, BC068517, BQ448420, DB001412
    Consensus CDS
    CCDS1972.1
    UniProtKB/Swiss-Prot
    Q6NUM9
    Related
    ENSP00000295802.4, ENST00000295802.9
    Conserved Domains (2) summary
    COG1233
    Location:69567
    COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
    cl21454
    Location:69569
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85341955..85354528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444828.1XP_047300784.1  all-trans-retinol 13,14-reductase isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791763.1 Reference GRCh38.p14 PATCHES

    Range
    268195..280766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85343946..85356519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)