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SIDT1 SID1 transmembrane family member 1 [ Homo sapiens (human) ]

Gene ID: 54847, updated on 3-May-2020

Summary

Official Symbol
SIDT1provided by HGNC
Official Full Name
SID1 transmembrane family member 1provided by HGNC
Primary source
HGNC:HGNC:25967
See related
Ensembl:ENSG00000072858 MIM:606816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SID1; SID-1
Summary
The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]
Expression
Broad expression in lymph node (RPKM 4.1), brain (RPKM 3.6) and 19 other tissues See more
Orthologs

Genomic context

See SIDT1 in Genome Data Viewer
Location:
3q13.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (113532296..113629579)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113251218..113348422)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 44 Neighboring gene CFAP44 antisense RNA 1 Neighboring gene microRNA 8076 Neighboring gene spindle and centriole associated protein 1 Neighboring gene microRNA 4446 Neighboring gene RNA, 7SL, cytoplasmic 767, pseudogene Neighboring gene upstream transcription factor family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • FLJ20174, B830021E24Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dsRNA transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SID1 transmembrane family member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054720.1 RefSeqGene

    Range
    5598..102802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308350.1NP_001295279.1  SID1 transmembrane family member 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001295279.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC055740, AC112128, AI004220, BC117222
    Consensus CDS
    CCDS77790.1
    UniProtKB/Swiss-Prot
    Q9NXL6
    Related
    ENSP00000377416.4, ENST00000393830.4
    Conserved Domains (1) summary
    pfam13965
    Location:187811
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  2. NM_001322294.2NP_001309223.1  SID1 transmembrane family member 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
    Conserved Domains (1) summary
    pfam13965
    Location:187812
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  3. NM_001322295.2NP_001309224.1  SID1 transmembrane family member 1 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
    Conserved Domains (1) summary
    pfam13965
    Location:187783
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  4. NM_001322296.2NP_001309225.1  SID1 transmembrane family member 1 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
    Conserved Domains (1) summary
    pfam13965
    Location:187749
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  5. NM_001322297.2NP_001309226.1  SID1 transmembrane family member 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
    Conserved Domains (1) summary
    pfam13965
    Location:36660
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  6. NM_001322298.2NP_001309227.1  SID1 transmembrane family member 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
    Conserved Domains (1) summary
    pfam13965
    Location:68630
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  7. NM_001322299.2NP_001309228.1  SID1 transmembrane family member 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220, BC143778
    Conserved Domains (1) summary
    pfam13965
    Location:2559
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  8. NM_001322300.2NP_001309229.1  SID1 transmembrane family member 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
    Conserved Domains (1) summary
    pfam13965
    Location:12384
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  9. NM_017699.3NP_060169.2  SID1 transmembrane family member 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_060169.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AI004220, AK000181, BE839090, BG484269, DA217300, DA337075, DB217586
    Consensus CDS
    CCDS2974.1
    UniProtKB/Swiss-Prot
    Q9NXL6
    Related
    ENSP00000264852.4, ENST00000264852.8
    Conserved Domains (1) summary
    pfam13965
    Location:187806
    SID-1_RNA_chan; dsRNA-gated channel SID-1

RNA

  1. NR_136280.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
  2. NR_136281.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
  3. NR_136282.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220, BC143776
  4. NR_136283.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
  5. NR_136284.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220
  6. NR_136285.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC055740, AC112128, AI004220

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    113532296..113629579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006665.2XP_016862154.1  SID1 transmembrane family member 1 isoform X4

  2. XM_011512941.3XP_011511243.1  SID1 transmembrane family member 1 isoform X3

    Conserved Domains (1) summary
    pfam13965
    Location:187774
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  3. XM_011512939.3XP_011511241.1  SID1 transmembrane family member 1 isoform X1

    Conserved Domains (1) summary
    pfam13965
    Location:187807
    SID-1_RNA_chan; dsRNA-gated channel SID-1
  4. XM_017006664.2XP_016862153.1  SID1 transmembrane family member 1 isoform X2

  5. XM_017006666.1XP_016862155.1  SID1 transmembrane family member 1 isoform X5

  6. XM_017006667.2XP_016862156.1  SID1 transmembrane family member 1 isoform X6

  7. XM_017006668.2XP_016862157.1  SID1 transmembrane family member 1 isoform X7

    Conserved Domains (1) summary
    pfam13965
    Location:12384
    SID-1_RNA_chan; dsRNA-gated channel SID-1

RNA

  1. XR_001740185.2 RNA Sequence

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