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WBP1L WW domain binding protein 1 like [ Homo sapiens (human) ]

Gene ID: 54838, updated on 22-Aug-2020

Summary

Official Symbol
WBP1Lprovided by HGNC
Official Full Name
WW domain binding protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:23510
See related
Ensembl:ENSG00000166272 MIM:611129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPA1L; OPAL1; C10orf26
Expression
Ubiquitous expression in thyroid (RPKM 20.1), adrenal (RPKM 15.0) and 25 other tissues See more
Orthologs

Genomic context

See WBP1L in Genome Data Viewer
Location:
10q24.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102742708..102816267)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104503727..104576022)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378460 Neighboring gene tripartite motif containing 8 Neighboring gene ADP ribosylation factor like GTPase 3 Neighboring gene sideroflexin 2 Neighboring gene RNA, U6 small nuclear 1231, pseudogene Neighboring gene CYP17A1 promoter Neighboring gene CYP17A1 antisense RNA 1 Neighboring gene cytochrome P450 family 17 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20154, FLJ20367, MGC125648

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WW domain binding protein 1-like
Names
outcome predictor in acute leukemia 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083913.2NP_001077382.1  WW domain binding protein 1-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_001077382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL358790, AL391121, AY656171, CX163170
    Consensus CDS
    CCDS44473.1
    UniProtKB/Swiss-Prot
    Q9NX94
    Related
    ENSP00000414721.1, ENST00000448841.7
    Conserved Domains (2) summary
    pfam11669
    Location:43144
    WBP-1; WW domain-binding protein 1
    PHA03249
    Location:159280
    PHA03249; DNA packaging tegument protein UL25; Provisional
  2. NM_017787.5NP_060257.4  WW domain binding protein 1-like isoform 2

    See identical proteins and their annotated locations for NP_060257.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon at its 5' end, compared to variant 1, resulting in a unique 5' UTR and use of a distinct translation initiation codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AL358790, AY656171, DA797839
    Consensus CDS
    CCDS7540.1
    UniProtKB/Swiss-Prot
    Q9NX94
    Related
    ENSP00000358905.4, ENST00000369889.5
    Conserved Domains (2) summary
    pfam11669
    Location:22123
    WBP-1; WW domain-binding protein 1
    PHA03249
    Location:138259
    PHA03249; DNA packaging tegument protein UL25; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    102742708..102816267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016360.1XP_016871849.1  WW domain binding protein 1-like isoform X2

  2. XM_011539913.2XP_011538215.1  WW domain binding protein 1-like isoform X1

    Conserved Domains (2) summary
    pfam11669
    Location:34135
    WBP-1; WW domain-binding protein 1
    PHA03249
    Location:150271
    PHA03249; DNA packaging tegument protein UL25; Provisional
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