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WBP1L WW domain binding protein 1 like [ Homo sapiens (human) ]

Gene ID: 54838, updated on 22-Sep-2022

Summary

Official Symbol
WBP1Lprovided by HGNC
Official Full Name
WW domain binding protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:23510
See related
Ensembl:ENSG00000166272 MIM:611129; AllianceGenome:HGNC:23510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPA1L; OPAL1; C10orf26
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to act upstream of or within CXCL12-activated CXCR4 signaling pathway; hemopoiesis; and positive regulation of protein ubiquitination. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 20.1), adrenal (RPKM 15.0) and 25 other tissues See more
Orthologs
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Genomic context

See WBP1L in Genome Data Viewer
Location:
10q24.32
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102743948..102816262)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103629750..103702045)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104503705..104576019)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 3 Neighboring gene sideroflexin 2 Neighboring gene RNA, U6 small nuclear 1231, pseudogene Neighboring gene CYP17A1 promoter Neighboring gene CYP17A1 antisense RNA 1 Neighboring gene cytochrome P450 family 17 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20154, FLJ20367, MGC125648

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CXCL12-activated CXCR4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WW domain binding protein 1-like
Names
outcome predictor in acute leukemia 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083913.2NP_001077382.1  WW domain binding protein 1-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_001077382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL358790, AL391121, AY656171, CX163170
    Consensus CDS
    CCDS44473.1
    UniProtKB/Swiss-Prot
    Q9NX94
    Related
    ENSP00000414721.1, ENST00000448841.7
    Conserved Domains (2) summary
    pfam11669
    Location:43144
    WBP-1; WW domain-binding protein 1
    PHA03249
    Location:159280
    PHA03249; DNA packaging tegument protein UL25; Provisional
  2. NM_017787.5NP_060257.4  WW domain binding protein 1-like isoform 2

    See identical proteins and their annotated locations for NP_060257.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon at its 5' end, compared to variant 1, resulting in a unique 5' UTR and use of a distinct translation initiation codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AL358790, AY656171, DA797839
    Consensus CDS
    CCDS7540.1
    UniProtKB/Swiss-Prot
    Q5F2G6, Q9NX94
    Related
    ENSP00000358905.4, ENST00000369889.5
    Conserved Domains (2) summary
    pfam11669
    Location:22123
    WBP-1; WW domain-binding protein 1
    PHA03249
    Location:138259
    PHA03249; DNA packaging tegument protein UL25; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    102743948..102816262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539913.3XP_011538215.1  WW domain binding protein 1-like isoform X1

    Conserved Domains (2) summary
    pfam11669
    Location:34135
    WBP-1; WW domain-binding protein 1
    PHA03249
    Location:150271
    PHA03249; DNA packaging tegument protein UL25; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103629750..103702045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)