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SWT1 SWT1 RNA endoribonuclease homolog [ Homo sapiens (human) ]

Gene ID: 54823, updated on 5-Aug-2022

Summary

Official Symbol
SWT1provided by HGNC
Official Full Name
SWT1 RNA endoribonuclease homologprovided by HGNC
Primary source
HGNC:HGNC:16785
See related
Ensembl:ENSG00000116668 MIM:619513; AllianceGenome:HGNC:16785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsSwt1; C1orf26
Summary
Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 13.8), bone marrow (RPKM 2.1) and 20 other tissues See more
Orthologs
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Genomic context

See SWT1 in Genome Data Viewer
Location:
1q25.3
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (185157060..185291781)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (184513970..184648685)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185126192..185260913)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 72 Neighboring gene ring finger protein 2 Neighboring gene ferritin heavy chain 1 pseudogene 25 Neighboring gene tRNA methyltransferase 1 like Neighboring gene ribosomal protein L22 pseudogene 24 Neighboring gene ribosomal protein L5 pseudogene 5 Neighboring gene uncharacterized LOC105371651 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 pseudogene Neighboring gene influenza virus NS1A binding protein Neighboring gene microtubule associated protein 1 light chain 3 beta pseudogene Neighboring gene CBS mRNA stabilizing lncRNA

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20121, FLJ35944

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional protein SWT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105518.2NP_001098988.1  transcriptional protein SWT1

    See identical proteins and their annotated locations for NP_001098988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF288392, AK000128, AK127980, BI756018, DB453411, DB518900
    Consensus CDS
    CCDS1367.1
    UniProtKB/Swiss-Prot
    Q5T5J6, Q9NXQ0
    UniProtKB/TrEMBL
    B3KXU9
    Related
    ENSP00000356471.3, ENST00000367501.7
    Conserved Domains (1) summary
    cd18727
    Location:391532
    PIN_Swt1-like; VapC-like PIN domain of Saccharomyces cerevisiae Swt1p, human SWT1 and related proteins
  2. NM_017673.7NP_060143.4  transcriptional protein SWT1

    See identical proteins and their annotated locations for NP_060143.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF288392, AK000128, BC030781, BI756018, DB518900
    Consensus CDS
    CCDS1367.1
    UniProtKB/Swiss-Prot
    Q5T5J6, Q9NXQ0
    Related
    ENSP00000356470.4, ENST00000367500.9
    Conserved Domains (1) summary
    cd18727
    Location:391532
    PIN_Swt1-like; VapC-like PIN domain of Saccharomyces cerevisiae Swt1p, human SWT1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    185157060..185291781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245271.3XP_005245328.1  transcriptional protein SWT1 isoform X1

    See identical proteins and their annotated locations for XP_005245328.1

    Conserved Domains (1) summary
    cd09880
    Location:396537
    PIN_Smg5-Smg6-like; PIN domain
  2. XM_047423246.1XP_047279202.1  transcriptional protein SWT1 isoform X3

  3. XM_017001528.3XP_016857017.1  transcriptional protein SWT1 isoform X3

  4. XM_017001530.3XP_016857019.1  transcriptional protein SWT1 isoform X5

  5. XM_011509657.2XP_011507959.1  transcriptional protein SWT1 isoform X1

    See identical proteins and their annotated locations for XP_011507959.1

    Conserved Domains (1) summary
    cd09880
    Location:396537
    PIN_Smg5-Smg6-like; PIN domain
  6. XM_005245273.2XP_005245330.1  transcriptional protein SWT1 isoform X1

    See identical proteins and their annotated locations for XP_005245330.1

    Conserved Domains (1) summary
    cd09880
    Location:396537
    PIN_Smg5-Smg6-like; PIN domain
  7. XM_017001527.2XP_016857016.1  transcriptional protein SWT1 isoform X2

    UniProtKB/Swiss-Prot
    Q5T5J6, Q9NXQ0
    Conserved Domains (1) summary
    cd18727
    Location:391532
    PIN_Swt1-like; VapC-like PIN domain of Saccharomyces cerevisiae Swt1p, human SWT1 and related proteins
  8. XM_047423249.1XP_047279205.1  transcriptional protein SWT1 isoform X6

  9. XM_047423243.1XP_047279199.1  transcriptional protein SWT1 isoform X2

    UniProtKB/Swiss-Prot
    Q9NXQ0
  10. XM_024447752.2XP_024303520.1  transcriptional protein SWT1 isoform X1

    Conserved Domains (1) summary
    cd09880
    Location:396537
    PIN_Smg5-Smg6-like; PIN domain
  11. XM_024447754.2XP_024303522.1  transcriptional protein SWT1 isoform X2

    UniProtKB/Swiss-Prot
    Q9NXQ0
    Conserved Domains (1) summary
    cd18727
    Location:391532
    PIN_Swt1-like; VapC-like PIN domain of Saccharomyces cerevisiae Swt1p, human SWT1 and related proteins
  12. XM_024447753.2XP_024303521.1  transcriptional protein SWT1 isoform X1

    Conserved Domains (1) summary
    cd09880
    Location:396537
    PIN_Smg5-Smg6-like; PIN domain
  13. XM_047423248.1XP_047279204.1  transcriptional protein SWT1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    184513970..184648685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)