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ALKBH4 alkB homolog 4, lysine demethylase [ Homo sapiens (human) ]

Gene ID: 54784, updated on 13-Mar-2020

Summary

Official Symbol
ALKBH4provided by HGNC
Official Full Name
alkB homolog 4, lysine demethylaseprovided by HGNC
Primary source
HGNC:HGNC:21900
See related
Ensembl:ENSG00000160993 MIM:613302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABH4
Expression
Ubiquitous expression in brain (RPKM 3.1), spleen (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See ALKBH4 in Genome Data Viewer
Location:
7q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102456220..102464863, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102096667..102105321, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC105375433 Neighboring gene microRNA 548o Neighboring gene ORAI calcium release-activated calcium modulator 2 Neighboring gene microRNA 5090 Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
demethylase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidative DNA demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA demethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
cleavage furrow ingression IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidative DNA demethylation IEA
Inferred from Electronic Annotation
more info
 
oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein demethylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
Names
DNA N6-methyl adenine demethylase ALKBH4
alkB homolog 4, lysine demthylase
alkB, alkylation repair homolog 4
alkylated DNA repair protein alkB homolog 4
lysine-specific demethylase ALKBH4
probable alpha-ketoglutarate-dependent dioxygenase ABH4
NP_060091.1
XP_005250521.1
XP_005250522.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017621.4NP_060091.1  alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

    See identical proteins and their annotated locations for NP_060091.1

    Status: VALIDATED

    Source sequence(s)
    BC017096, BX353099
    Consensus CDS
    CCDS5723.1
    UniProtKB/Swiss-Prot
    Q9NXW9
    Related
    ENSP00000292566.3, ENST00000292566.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102456220..102464863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250464.3XP_005250521.1  alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform X1

    See identical proteins and their annotated locations for XP_005250521.1

    UniProtKB/Swiss-Prot
    Q9NXW9
  2. XM_005250465.2XP_005250522.1  alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform X2

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