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OTUD4 OTU deubiquitinase 4 [ Homo sapiens (human) ]

Gene ID: 54726, updated on 4-Dec-2022

Summary

Official Symbol
OTUD4provided by HGNC
Official Full Name
OTU deubiquitinase 4provided by HGNC
Primary source
HGNC:HGNC:24949
See related
Ensembl:ENSG00000164164 MIM:611744; AllianceGenome:HGNC:24949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIN1; DUBA6; HSHIN1
Summary
Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in testis (RPKM 19.7), bone marrow (RPKM 11.0) and 25 other tissues See more
Orthologs
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Genomic context

See OTUD4 in Genome Data Viewer
Location:
4q31.21
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (145133650..145180589, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (148451040..148497987, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (146054802..146101741, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 10 Neighboring gene RN7SK pseudogene 235 Neighboring gene ATP binding cassette subfamily E member 1 Neighboring gene uncharacterized LOC124900794 Neighboring gene uncharacterized LOC105377465

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1046, DKFZp434I0721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
OTU domain-containing protein 4
Names
HIV-1 induced protein HIN-1
NP_001096123.1
NP_001352986.1
NP_001352987.1
NP_059963.1
XP_011530342.2
XP_011530343.2
XP_011530344.1
XP_047271794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047157.1 RefSeqGene

    Range
    4385..51324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001102653.1NP_001096123.1  OTU domain-containing protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001096123.1

    Status: REVIEWED

    Source sequence(s)
    AC096757, BC118572, DB446926
    Consensus CDS
    CCDS47139.1
    UniProtKB/Swiss-Prot
    Q01804
    Related
    ENSP00000409279.2, ENST00000454497.6
    Conserved Domains (1) summary
    cl19932
    Location:356
    OTU; OTU-like cysteine protease
  2. NM_001366057.1NP_001352986.1  OTU domain-containing protein 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC096757
    Consensus CDS
    CCDS93644.1
    UniProtKB/Swiss-Prot
    Q9UPV6
    Related
    ENSP00000395487.2, ENST00000447906.8
    Conserved Domains (2) summary
    cl19932
    Location:42121
    OTU; OTU-like cysteine protease
    cl26464
    Location:543886
    Atrophin-1; Atrophin-1 family
  3. NM_001366058.1NP_001352987.1  OTU domain-containing protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC096757
    Conserved Domains (1) summary
    cl19932
    Location:42121
    OTU; OTU-like cysteine protease
  4. NM_017493.7NP_059963.1  OTU domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_059963.1

    Status: REVIEWED

    Source sequence(s)
    AC096757, X68242
    Consensus CDS
    CCDS3764.1
    UniProtKB/Swiss-Prot
    Q01804
    Related
    ENSP00000424192.2, ENST00000509620.6
    Conserved Domains (1) summary
    cl19932
    Location:356
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    145133650..145180589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415838.1XP_047271794.1  OTU domain-containing protein 4 isoform X3

  2. XM_011532041.3XP_011530343.2  OTU domain-containing protein 4 isoform X2

  3. XM_011532040.3XP_011530342.2  OTU domain-containing protein 4 isoform X1

  4. XM_011532042.4XP_011530344.1  OTU domain-containing protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011530344.1

    Conserved Domains (1) summary
    cl19932
    Location:363
    OTU; OTU-like cysteine protease

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    148451040..148497987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199324.2: Suppressed sequence

    Description
    NM_199324.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.