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Gsdme gasdermin E [ Mus musculus (house mouse) ]

Gene ID: 54722, updated on 18-Sep-2018

Summary

Official Symbol
Gsdmeprovided by MGI
Official Full Name
gasdermin Eprovided by MGI
Primary source
MGI:MGI:1889850
See related
Ensembl:ENSMUSG00000029821 Vega:OTTMUSG00000035970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dfna5; Fin15; Dfna5h; EG14210; 2310037D07Rik; 4932441K13Rik
Expression
Broad expression in large intestine adult (RPKM 17.8), CNS E18 (RPKM 5.1) and 16 other tissues See more
Orthologs

Genomic context

See Gsdme in Genome Data Viewer
Location:
6; 6 B2.3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (50207401..50262862, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (50157402..50211768, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38805 Neighboring gene membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) Neighboring gene oxysterol binding protein-like 3 Neighboring gene predicted gene, 40372 Neighboring gene predicted gene, 31279

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cardiolipin binding IDA
Inferred from Direct Assay
more info
PubMed 
cardiolipin binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell death ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
inner ear receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
programmed cell death IEA
Inferred from Electronic Annotation
more info
 
pyroptosis ISO
Inferred from Sequence Orthology
more info
 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gasdermin-E; non-syndromic hearing impairment protein 5 homolog
Names
deafness associated tumor suppressor
deafness, autosomal dominant 5 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018769.4NP_061239.1  gasdermin-E precursor

    See identical proteins and their annotated locations for NP_061239.1

    Status: VALIDATED

    Source sequence(s)
    AC153819
    Consensus CDS
    CCDS20130.1
    UniProtKB/Swiss-Prot
    Q9Z2D3
    Related
    ENSMUSP00000126759.1, ENSMUST00000170142.7
    Conserved Domains (1) summary
    pfam04598
    Location:1464
    Gasdermin; Gasdermin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    50207401..50262862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506402.3XP_006506465.1  non-syndromic hearing impairment protein 5 homolog isoform X1

    Conserved Domains (1) summary
    pfam04598
    Location:1397
    Gasdermin; Gasdermin family
  2. XM_011241414.2XP_011239716.1  non-syndromic hearing impairment protein 5 homolog isoform X2

    Related
    ENSMUSP00000098952.3, OTTMUSP00000050975, ENSMUST00000101405.9, OTTMUST00000092301
    Conserved Domains (1) summary
    pfam04598
    Location:1398
    Gasdermin; Gasdermin family

RNA

  1. XR_001785156.1 RNA Sequence

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