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Rcan1 regulator of calcineurin 1 [ Mus musculus (house mouse) ]

Gene ID: 54720, updated on 21-Apr-2024

Summary

Official Symbol
Rcan1provided by MGI
Official Full Name
regulator of calcineurin 1provided by MGI
Primary source
MGI:MGI:1890564
See related
Ensembl:ENSMUSG00000022951 AllianceGenome:MGI:1890564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSP1; DSC1; RCN1; Dscr1; MCIP1; CALP1L; Adapt78
Summary
Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity and identical protein binding activity. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; response to ischemia; and short-term memory. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of calcineurin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.8), heart adult (RPKM 14.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
16 C4; 16 53.6 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (92188839..92263057, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (92391951..92466169, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Isk-related subfamily, member 1 Neighboring gene predicted gene, 30163 Neighboring gene predicted gene, 29805 Neighboring gene VISTA enhancer mm107 Neighboring gene predicted gene, 41498 Neighboring gene STARR-seq mESC enhancer starr_41512 Neighboring gene predicted gene, 46555 Neighboring gene STARR-positive B cell enhancer ABC_E1496 Neighboring gene STARR-seq mESC enhancer starr_41514 Neighboring gene RIKEN cDNA 2410124H12 gene Neighboring gene STARR-seq mESC enhancer starr_41517 Neighboring gene chloride intracellular channel 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 2410048A02Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcineurin-NFAT signaling cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within short-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcipressin-1
Names
calcineurin inhibitor
down syndrome critical region protein 1 homolog
myocyte-enriched calcineurin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081549.2NP_001075018.1  calcipressin-1 isoform 1

    See identical proteins and their annotated locations for NP_001075018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146764, BY276032, BY454038
    Consensus CDS
    CCDS37405.1
    UniProtKB/Swiss-Prot
    Q7TNY3, Q91WQ4, Q9JHG6, Q9JK50, Q9JK51, Q9JKK2, Q9JKK3
    Related
    ENSMUSP00000060394.9, ENSMUST00000060005.15
    Conserved Domains (1) summary
    pfam04847
    Location:75244
    Calcipressin; Calcipressin
  2. NM_019466.4NP_062339.2  calcipressin-1 isoform 2

    See identical proteins and their annotated locations for NP_062339.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC162305, AK077283, AK146764, BY454038
    Consensus CDS
    CCDS28337.1
    UniProtKB/TrEMBL
    Q542V6
    Related
    ENSMUSP00000023672.8, ENSMUST00000023672.10
    Conserved Domains (1) summary
    pfam04847
    Location:22191
    Calcipressin; Calcipressin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    92188839..92263057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)