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Serpina3h serine (or cysteine) peptidase inhibitor, clade A, member 3H [ Mus musculus (house mouse) ]

Gene ID: 546546, updated on 2-Nov-2024

Summary

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Official Symbol
Serpina3hprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 3Hprovided by MGI
Primary source
MGI:MGI:2182839
See related
Ensembl:ENSMUSG00000121484 AllianceGenome:MGI:2182839
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6C28; Spi2
Summary
Acts upstream of or within response to cytokine and response to peptide hormone. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 2.7), subcutaneous fat pad adult (RPKM 2.6) and 16 other tissues See more
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Genomic context

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See Serpina3h in Genome Data Viewer
Location:
12 E; 12 53.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104214155..104220664)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104247896..104254405)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene developmentally regulated GTP binding protein 2 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3G Neighboring gene STARR-seq mESC enhancer starr_33134 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3I Neighboring gene microRNA 12183 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain. Inglis JD, et al. EMBO J, 1991 Feb. PMID 1991447, Free PMC Article
  2. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Forsyth S, et al. Genomics, 2003 Mar. PMID 12659817
  3. Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. Winkler IG, et al. J Exp Med, 2005 Apr 4. PMID 15795238, Free PMC Article
  4. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
  5. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Other Names

  • alpha-1 antiproteinase, antitrypsin
  • serine (or cysteine) proteinase inhibitor, clade A, member 3H

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within response to cytokine IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to peptide hormone IDA
Inferred from Direct Assay
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033450.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC142112
    Related
    ENSMUST00000245222.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104214155..104220664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034870.2: Suppressed sequence

    Description
    NM_001034870.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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