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Wdr45 WD repeat domain 45 [ Mus musculus (house mouse) ]

Gene ID: 54636, updated on 6-Jun-2024

Summary

Official Symbol
Wdr45provided by MGI
Official Full Name
WD repeat domain 45provided by MGI
Primary source
MGI:MGI:1859606
See related
Ensembl:ENSMUSG00000039382 AllianceGenome:MGI:1859606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JM5; Sfc19; Wdrx1; WIPI-4; DXImx38e
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity; phosphatidylinositol-3-phosphate binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; autophagy of nucleus; and protein localization to phagophore assembly site. Predicted to be located in phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and lung. Used to study neurodegeneration with brain iron accumulation 5. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to human WDR45 (WD repeat domain 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 12.1), genital fat pad adult (RPKM 9.0) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr45 in Genome Data Viewer
Location:
X A1.1; X 3.48 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7588212..7594439)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7721987..7728201)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene x_14.1 Neighboring gene G patch domain and KOW motifs Neighboring gene STARR-seq mESC enhancer starr_46667 Neighboring gene STARR-seq mESC enhancer starr_46668 Neighboring gene STARR-seq mESC enhancer starr_46669 Neighboring gene PRA1 domain family 2 Neighboring gene coiled-coil domain containing 120

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
WD repeat domain phosphoinositide-interacting protein 4
Names
WD repeat domain, X-linked 1
WD repeat-containing protein 45

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290792.2NP_001277721.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    See identical proteins and their annotated locations for NP_001277721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1-3 and 5-13 all encode the same isoform (a).
    Source sequence(s)
    AL671995
    Consensus CDS
    CCDS29970.1
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
    Related
    ENSMUSP00000041456.3, ENSMUST00000043045.10
    Conserved Domains (2) summary
    sd00039
    Location:196232
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:187274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001290794.2NP_001277723.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    See identical proteins and their annotated locations for NP_001277723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-13 all encode the same isoform (a).
    Source sequence(s)
    AL671995
    Consensus CDS
    CCDS29970.1
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
    Related
    ENSMUSP00000111351.2, ENSMUST00000115687.8
    Conserved Domains (2) summary
    sd00039
    Location:196232
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:187274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001290795.2NP_001277724.1  WD repeat domain phosphoinositide-interacting protein 4 isoform b

    See identical proteins and their annotated locations for NP_001277724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 4 and 17 both encode the same isoform (b).
    Source sequence(s)
    AL671995
    Consensus CDS
    CCDS72331.1
    UniProtKB/TrEMBL
    A0A140LHC1
    Related
    ENSMUSP00000111352.2, ENSMUST00000115688.8
    Conserved Domains (1) summary
    cl29593
    Location:186224
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001426270.1NP_001413199.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  5. NM_001426271.1NP_001413200.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  6. NM_001426273.1NP_001413202.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  7. NM_001426274.1NP_001413203.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  8. NM_001426275.1NP_001413204.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  9. NM_001426276.1NP_001413205.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  10. NM_001426277.1NP_001413206.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  11. NM_001426278.1NP_001413207.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  12. NM_001426279.1NP_001413208.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
  13. NM_001426280.1NP_001413209.1  WD repeat domain phosphoinositide-interacting protein 4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/TrEMBL
    A0A140LJJ0
    Related
    ENSMUSP00000147232.2, ENSMUST00000207589.2
  14. NM_001426281.1NP_001413210.1  WD repeat domain phosphoinositide-interacting protein 4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/TrEMBL
    A0A140LJJ0
  15. NM_001426282.1NP_001413211.1  WD repeat domain phosphoinositide-interacting protein 4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/TrEMBL
    A0A140LJJ0
  16. NM_001426283.1NP_001413212.1  WD repeat domain phosphoinositide-interacting protein 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/TrEMBL
    A0A140LHC1
  17. NM_001426284.1NP_001413213.1  WD repeat domain phosphoinositide-interacting protein 4 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) encodes the longest isoform (d).
    Source sequence(s)
    AL671995
    UniProtKB/TrEMBL
    A2AEV5
  18. NM_001426286.1NP_001413215.1  WD repeat domain phosphoinositide-interacting protein 4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL671995
    UniProtKB/TrEMBL
    A0A140LJC8
    Related
    ENSMUSP00000147163.2, ENSMUST00000207675.2
  19. NM_172372.3NP_758960.1  WD repeat domain phosphoinositide-interacting protein 4 isoform a

    See identical proteins and their annotated locations for NP_758960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1-3 and 5-13 all encode the same isoform (a).
    Source sequence(s)
    AL671995
    Consensus CDS
    CCDS29970.1
    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
    Related
    ENSMUSP00000111353.4, ENSMUST00000115689.10
    Conserved Domains (2) summary
    sd00039
    Location:196232
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:187274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_189681.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671995
  2. NR_189682.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671995
  3. NR_189683.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671995

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7588212..7594439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162027.1XP_036017920.1  WD repeat domain phosphoinositide-interacting protein 4 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:87123
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:78165
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017318561.3XP_017174050.1  WD repeat domain phosphoinositide-interacting protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A140LHC1
    Conserved Domains (1) summary
    cl29593
    Location:186224
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006527662.3XP_006527725.1  WD repeat domain phosphoinositide-interacting protein 4 isoform X4

    See identical proteins and their annotated locations for XP_006527725.1

    Conserved Domains (2) summary
    sd00039
    Location:87123
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:78165
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_030251390.2XP_030107250.1  WD repeat domain phosphoinositide-interacting protein 4 isoform X1

    UniProtKB/Swiss-Prot
    A2AEV3, A2AEV4, Q91VM3, Q9CVF7, Q9JIG9
    UniProtKB/TrEMBL
    A2AEV5
    Conserved Domains (2) summary
    sd00039
    Location:196232
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:187274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...