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Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 54632, updated on 12-May-2024

Summary

Official Symbol
Ftsj1provided by MGI
Official Full Name
FtsJ RNA 2'-O-methyltransferase 1provided by MGI
Primary source
MGI:MGI:1859648
See related
Ensembl:ENSMUSG00000031171 AllianceGenome:MGI:1859648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ftsj; Ftsjl; Sfc12
Summary
Predicted to enable tRNA (cytosine-2'-O-)-methyltransferase activity and tRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in cytoplasmic translation and tRNA methylation. Predicted to be active in cytoplasm. Is expressed in ovary; oviduct; and uterus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.1), liver E14.5 (RPKM 8.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ftsj1 in Genome Data Viewer
Location:
X A1.1; X 3.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (8104907..8118609, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8238668..8252406, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene EBP cholestenol delta-isomerase Neighboring gene porcupine O-acyltransferase Neighboring gene STARR-seq mESC enhancer starr_46691 Neighboring gene predicted gene, 33135 Neighboring gene STARR-seq mESC enhancer starr_46693 Neighboring gene STARR-seq mESC enhancer starr_46694 Neighboring gene predicted gene, 54078 Neighboring gene solute carrier family 38, member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA (cytidine(32)-2'-O)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA (guanine(34)-2'-O)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA (guanine) methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA 2'-O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA nucleoside ribose methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in wobble position ribose methylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
Names
2'-O-ribose RNA methyltransferase TRM7 homolog
FtsJ RNA methyltransferase homolog 1
protein ftsJ homolog 1
putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
NP_001277359.1
NP_598752.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290430.2NP_001277359.1  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001277359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL805902
    Consensus CDS
    CCDS72340.1
    UniProtKB/TrEMBL
    Q8CBC7, Q8JZY1
    Related
    ENSMUSP00000111258.2, ENSMUST00000115595.8
    Conserved Domains (1) summary
    COG0293
    Location:4203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
  2. NM_133991.3NP_598752.2  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_598752.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL805902
    Consensus CDS
    CCDS29994.1
    UniProtKB/Swiss-Prot
    A2ALH2, Q8CBC7, Q8JZY1, Q91XA6
    Related
    ENSMUSP00000033513.4, ENSMUST00000033513.10
    Conserved Domains (1) summary
    COG0293
    Location:4203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    8104907..8118609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)