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CCNJ cyclin J [ Homo sapiens (human) ]

Gene ID: 54619, updated on 29-Mar-2020

Summary

Official Symbol
CCNJprovided by HGNC
Official Full Name
cyclin Jprovided by HGNC
Primary source
HGNC:HGNC:23434
See related
Ensembl:ENSG00000107443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA690P14.1
Expression
Ubiquitous expression in bone marrow (RPKM 3.4), testis (RPKM 2.6) and 25 other tissues See more
Orthologs

Genomic context

See CCNJ in Genome Data Viewer
Location:
10q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (96042848..96060870)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97803159..97820627)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene ENTPD1 antisense RNA 1 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene ribosomal protein L21 pseudogene 90 Neighboring gene microRNA 3157 Neighboring gene RNA, U6 small nuclear 271, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134375.2NP_001127847.1  cyclin-J isoform 1

    See identical proteins and their annotated locations for NP_001127847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK001757, AK025932, BC043175, BM789816
    Consensus CDS
    CCDS44462.1
    UniProtKB/Swiss-Prot
    Q5T5M9
    Related
    ENSP00000435373.2, ENST00000465148.3
    Conserved Domains (2) summary
    pfam02984
    Location:145251
    Cyclin_C; Cyclin, C-terminal domain
    cl25647
    Location:10246
    Cyclin_N2; N-terminal region of cyclin_N
  2. NM_001134376.2NP_001127848.1  cyclin-J isoform 3

    See identical proteins and their annotated locations for NP_001127848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 3) that lacks twelve internal amino acids, when compared to isoform 1.
    Source sequence(s)
    AK001757, AK025932, BC043175
    Consensus CDS
    CCDS44463.1
    UniProtKB/Swiss-Prot
    Q5T5M9
    Related
    ENSP00000384498.2, ENST00000403870.7
    Conserved Domains (2) summary
    pfam02984
    Location:145239
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:15109
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  3. NM_019084.5NP_061957.2  cyclin-J isoform 2

    See identical proteins and their annotated locations for NP_061957.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 2) that lacks eleven internal amino acids, when compared to isoform 1.
    Source sequence(s)
    AK001757, AK025932, BC043175
    Consensus CDS
    CCDS7445.1
    UniProtKB/Swiss-Prot
    Q5T5M9
    Related
    ENSP00000265992.5, ENST00000265992.9
    Conserved Domains (2) summary
    pfam02984
    Location:145240
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:15109
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    96042848..96060870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539885.2XP_011538187.1  cyclin-J isoform X4

    See identical proteins and their annotated locations for XP_011538187.1

    UniProtKB/Swiss-Prot
    Q5T5M9
    Conserved Domains (2) summary
    pfam02984
    Location:145251
    Cyclin_C; Cyclin, C-terminal domain
    cl25647
    Location:10246
    Cyclin_N2; N-terminal region of cyclin_N
  2. XM_017016354.1XP_016871843.1  cyclin-J isoform X1

  3. XM_017016355.1XP_016871844.1  cyclin-J isoform X2

  4. XM_017016356.1XP_016871845.1  cyclin-J isoform X3

  5. XM_005269921.3XP_005269978.1  cyclin-J isoform X5

    Conserved Domains (1) summary
    pfam02984
    Location:31137
    Cyclin_C; Cyclin, C-terminal domain
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