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Foxo4 forkhead box O4 [ Mus musculus (house mouse) ]

Gene ID: 54601, updated on 12-May-2024

Summary

Official Symbol
Foxo4provided by MGI
Official Full Name
forkhead box O4provided by MGI
Primary source
MGI:MGI:1891915
See related
Ensembl:ENSMUSG00000042903 AllianceGenome:MGI:1891915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
afx; Afxh; Mllt7
Summary
Enables sequence-specific DNA binding activity. Acts upstream of or within mitotic G2 DNA damage checkpoint signaling; negative regulation of cell population proliferation; and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; inner cell mass; and sensory organ. Orthologous to human FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 68.4), limb E14.5 (RPKM 10.1) and 21 other tissues See more
Orthologs
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Genomic context

See Foxo4 in Genome Data Viewer
Location:
X D; X 43.89 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100297855..100304479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101254261..101260873)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene sorting nexin 12 Neighboring gene predicted gene, 24061 Neighboring gene STARR-seq mESC enhancer starr_47642 Neighboring gene predicted gene, 22472 Neighboring gene STARR-seq mESC enhancer starr_47643 Neighboring gene predicted gene 614 Neighboring gene interleukin 2 receptor, gamma chain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
forkhead box protein O4
Names
fork head domain transcription factor AFX1
forkhead protein
myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018789.2NP_061259.1  forkhead box protein O4

    See identical proteins and their annotated locations for NP_061259.1

    Status: VALIDATED

    Source sequence(s)
    AL671926
    Consensus CDS
    CCDS41077.1
    UniProtKB/Swiss-Prot
    Q9WVH3
    UniProtKB/TrEMBL
    B1AUT2, B1AUT3
    Related
    ENSMUSP00000059420.5, ENSMUST00000062000.6
    Conserved Domains (4) summary
    pfam05887
    Location:683
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    cd00059
    Location:101181
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16675
    Location:359399
    FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
    pfam16676
    Location:466503
    FOXO-TAD; Transactivation domain of FOXO protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100297855..100304479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528139.3XP_006528202.1  forkhead box protein O4 isoform X1

    See identical proteins and their annotated locations for XP_006528202.1

    UniProtKB/TrEMBL
    Q3TZJ4, Q4KL34
    Conserved Domains (2) summary
    PHA03247
    Location:18130
    PHA03247; large tegument protein UL36; Provisional
    cl00061
    Location:101151
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...