Format

Send to:

Choose Destination

POU4F2 POU class 4 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 5458, updated on 1-Jun-2020

Summary

Official Symbol
POU4F2provided by HGNC
Official Full Name
POU class 4 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:9219
See related
Ensembl:ENSG00000151615 MIM:113725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN3B; BRN3.2; Brn-3b
Summary
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See POU4F2 in Genome Data Viewer
Location:
4q31.22
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (146638893..146642474)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (147560045..147563623)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 member 7 Neighboring gene microRNA 7849 Neighboring gene RNA, U1 small nuclear 44, pseudogene Neighboring gene tetratricopeptide repeat domain 29 Neighboring gene uncharacterized LOC105377474 Neighboring gene uncharacterized LOC105377473

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
axon extension IEA
Inferred from Electronic Annotation
more info
 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to estradiol stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxygen levels IEA
Inferred from Electronic Annotation
more info
 
dorsal root ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of amacrine cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of programmed cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
retina development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear euchromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
POU domain, class 4, transcription factor 2
Names
Brn3b POU domain transcription factor
POU domain protein
brain-3B
brain-specific homeobox/POU domain protein 3B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004575.3NP_004566.2  POU domain, class 4, transcription factor 2

    See identical proteins and their annotated locations for NP_004566.2

    Status: REVIEWED

    Source sequence(s)
    AC093887, BY796838, DB082745, U06233, X71488
    Consensus CDS
    CCDS34074.1
    UniProtKB/Swiss-Prot
    Q12837
    Related
    ENSP00000281321.3, ENST00000281321.3
    Conserved Domains (2) summary
    smart00352
    Location:250327
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:348401
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    146638893..146642474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center