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NECAB2 N-terminal EF-hand calcium binding protein 2 [ Homo sapiens (human) ]

Gene ID: 54550, updated on 1-Jul-2020

Summary

Official Symbol
NECAB2provided by HGNC
Official Full Name
N-terminal EF-hand calcium binding protein 2provided by HGNC
Primary source
HGNC:HGNC:23746
See related
Ensembl:ENSG00000103154 MIM:618130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EFCBP2; stip-2
Summary
The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016]
Expression
Biased expression in brain (RPKM 9.4), kidney (RPKM 3.0) and 3 other tissues See more
Orthologs

Genomic context

See NECAB2 in Genome Data Viewer
Location:
16q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (83968632..84002776)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84002237..84036379)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371371 Neighboring gene oxidative stress induced growth inhibitor 1 Neighboring gene solute carrier family 38 member 8 Neighboring gene RNA, 5S ribosomal pseudogene 432 Neighboring gene membrane bound transcription factor peptidase, site 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
A2A adenosine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 5 metabotropic glutamate receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-terminal EF-hand calcium-binding protein 2
Names
EF-hand calcium-binding protein 2
neuronal calcium binding 2
neuronal calcium-binding protein 2
synaptotagmin-interacting protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329748.1NP_001316677.1  N-terminal EF-hand calcium-binding protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC040169
  2. NM_001329749.2NP_001316678.1  N-terminal EF-hand calcium-binding protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC040169
    Consensus CDS
    CCDS82019.1
    UniProtKB/Swiss-Prot
    Q7Z6G3
    Related
    ENSP00000457354.1, ENST00000565691.5
    Conserved Domains (1) summary
    pfam03992
    Location:205275
    ABM; Antibiotic biosynthesis monooxygenase
  3. NM_019065.3NP_061938.2  N-terminal EF-hand calcium-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_061938.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC040169
    Consensus CDS
    CCDS10940.1
    UniProtKB/Swiss-Prot
    Q7Z6G3
    Related
    ENSP00000307449.4, ENST00000305202.8
    Conserved Domains (3) summary
    cd00051
    Location:65121
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam03992
    Location:288358
    ABM; Antibiotic biosynthesis monooxygenase
    pfam13499
    Location:65123
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    83968632..84002776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023317.2XP_016878806.1  N-terminal EF-hand calcium-binding protein 2 isoform X1

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