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ADAMTSL4 ADAMTS like 4 [ Homo sapiens (human) ]

Gene ID: 54507, updated on 5-Sep-2021

Summary

Official Symbol
ADAMTSL4provided by HGNC
Official Full Name
ADAMTS like 4provided by HGNC
Primary source
HGNC:HGNC:19706
See related
Ensembl:ENSG00000143382 MIM:610113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSRC1; ECTOL2; ADAMTSL-4
Summary
This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]
Expression
Biased expression in placenta (RPKM 57.7), lung (RPKM 14.8) and 11 other tissues See more
Orthologs
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Genomic context

See ADAMTSL4 in Genome Data Viewer
Location:
1q21.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (150549378..150560937)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150521884..150533413)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene focally amplified long non-coding RNA in epithelial cancer Neighboring gene CRISPRi-validated cis-regulatory element chr1.8461 Neighboring gene ADAMTSL4 antisense RNA 2 Neighboring gene microRNA 4257 Neighboring gene ADAMTSL4 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 473, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 600, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADAMTS-like protein 4
Names
thrombospondin repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012172.1 RefSeqGene

    Range
    4948..16516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288607.2NP_001275536.1  ADAMTS-like protein 4 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL122085, AL356356, AY358122, BC144581, CB960863, HY002139
    UniProtKB/Swiss-Prot
    Q6UY14
    UniProtKB/TrEMBL
    B7ZMJ3, Q9UFG7
    Related
    ENSP00000501255.1, ENST00000674058.1
    Conserved Domains (3) summary
    smart00209
    Location:938987
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:508618
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:9941023
    PLAC; PLAC (protease and lacunin) domain
  2. NM_001288608.2NP_001275537.1  ADAMTS-like protein 4 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001275537.1

    Status: REVIEWED

    Source sequence(s)
    AL356356
    Consensus CDS
    CCDS72908.1
    UniProtKB/Swiss-Prot
    Q6UY14
    UniProtKB/TrEMBL
    B7ZMJ3, Q9UFG7
    Related
    ENSP00000358035.5, ENST00000369039.9
    Conserved Domains (3) summary
    smart00209
    Location:10001049
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:508622
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10561085
    PLAC; PLAC (protease and lacunin) domain
  3. NM_001378596.1NP_001365525.1  ADAMTS-like protein 4 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL356356
    Conserved Domains (5) summary
    smart00209
    Location:4777
    TSP1; Thrombospondin type 1 repeats
    PHA03247
    Location:143392
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:485599
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10331062
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:727783
    TSP1_ADAMTS; Thrombospondin type 1 domain
  4. NM_019032.6NP_061905.2  ADAMTS-like protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061905.2

    Status: REVIEWED

    Source sequence(s)
    AL356356
    Consensus CDS
    CCDS955.1
    UniProtKB/Swiss-Prot
    Q6UY14
    UniProtKB/TrEMBL
    B7ZMJ3, Q9UFG7
    Related
    ENSP00000271643.4, ENST00000271643.9
    Conserved Domains (5) summary
    smart00209
    Location:4777
    TSP1; Thrombospondin type 1 repeats
    PHA03247
    Location:143392
    PHA03247; large tegument protein UL36; Provisional
    pfam05986
    Location:485599
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10331062
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:727783
    TSP1_ADAMTS; Thrombospondin type 1 domain
  5. NM_025008.5NP_079284.2  ADAMTS-like protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_079284.2

    Status: REVIEWED

    Source sequence(s)
    AL356356, AY358122, CB960863, CX164541, HY002139
    Consensus CDS
    CCDS30852.1
    UniProtKB/Swiss-Prot
    Q6UY14
    Related
    ENSP00000358037.5, ENST00000369041.9
    Conserved Domains (2) summary
    smart00209
    Location:786841
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:485599
    ADAM_spacer1; ADAM-TS Spacer 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    150549378..150560937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001506.2XP_016856995.1  ADAMTS-like protein 4 isoform X3

    UniProtKB/Swiss-Prot
    Q6UY14
    Conserved Domains (3) summary
    smart00209
    Location:10001049
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:508622
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10561085
    PLAC; PLAC (protease and lacunin) domain
  2. XM_011509648.3XP_011507950.1  ADAMTS-like protein 4 isoform X3

    See identical proteins and their annotated locations for XP_011507950.1

    UniProtKB/Swiss-Prot
    Q6UY14
    Conserved Domains (3) summary
    smart00209
    Location:10001049
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:508622
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10561085
    PLAC; PLAC (protease and lacunin) domain
  3. XM_011509649.3XP_011507951.1  ADAMTS-like protein 4 isoform X4

    Conserved Domains (2) summary
    smart00209
    Location:80110
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:541655
    ADAM_spacer1; ADAM-TS Spacer 1
  4. XM_011509650.3XP_011507952.1  ADAMTS-like protein 4 isoform X5

    Conserved Domains (2) summary
    smart00209
    Location:80110
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:541655
    ADAM_spacer1; ADAM-TS Spacer 1
  5. XM_011509644.3XP_011507946.1  ADAMTS-like protein 4 isoform X1

    Conserved Domains (3) summary
    smart00209
    Location:10331082
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:541655
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10891118
    PLAC; PLAC (protease and lacunin) domain
  6. XM_011509645.3XP_011507947.1  ADAMTS-like protein 4 isoform X2

    Conserved Domains (3) summary
    smart00209
    Location:10101059
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:518632
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10661095
    PLAC; PLAC (protease and lacunin) domain
  7. XM_011509651.2XP_011507953.1  ADAMTS-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011507953.1

    Conserved Domains (3) summary
    smart00209
    Location:536585
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:44158
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:592621
    PLAC; PLAC (protease and lacunin) domain
  8. XM_011509652.2XP_011507954.1  ADAMTS-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_011507954.1

    Conserved Domains (3) summary
    smart00209
    Location:536585
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:44158
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:592621
    PLAC; PLAC (protease and lacunin) domain
  9. XM_017001507.1XP_016856996.1  ADAMTS-like protein 4 isoform X7

RNA

  1. XR_921844.3 RNA Sequence

  2. XR_001737242.2 RNA Sequence

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