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ZDHHC13 zinc finger DHHC-type containing 13 [ Homo sapiens (human) ]

Gene ID: 54503, updated on 5-Aug-2018

Summary

Official Symbol
ZDHHC13provided by HGNC
Official Full Name
zinc finger DHHC-type containing 13provided by HGNC
Primary source
HGNC:HGNC:18413
See related
Ensembl:ENSG00000177054 MIM:612815; Vega:OTTHUMG00000166099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP14L; HIP3RP
Expression
Ubiquitous expression in esophagus (RPKM 18.5), urinary bladder (RPKM 11.0) and 24 other tissues See more
Orthologs

Genomic context

See ZDHHC13 in Genome Data Viewer
Location:
11p15.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (19117099..19176420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19138681..19197967)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member X3 pseudogene Neighboring gene MAS related GPR family member X2 Neighboring gene VISTA enhancer hs2144 Neighboring gene uncharacterized LOC105376580 Neighboring gene VISTA enhancer hs2145 Neighboring gene cysteine and glycine rich protein 3 Neighboring gene E2F transcription factor 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10852, FLJ10941, MGC64994

Gene Ontology Provided by GOA

Function Evidence Code Pubs
magnesium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi-associated vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
palmitoyltransferase ZDHHC13
Names
DHHC-13
HIP14-related protein
huntingtin interacting protein HIP3RP
huntingtin-interacting protein 14-related protein
probable palmitoyltransferase ZDHHC13
putative MAPK-activating protein PM03
putative NF-kappa-B-activating protein 209
zinc finger DHHC domain-containing protein 13
zinc finger, DHHC domain containing 13
NP_001001483.1
NP_061901.2
XP_005253053.1
XP_011518495.1
XP_011518496.1
XP_011518497.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001483.2NP_001001483.1  palmitoyltransferase ZDHHC13 isoform 2

    See identical proteins and their annotated locations for NP_001001483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC050690, BC056152
    Consensus CDS
    CCDS44551.1
    UniProtKB/Swiss-Prot
    Q8IUH4
    Related
    ENSP00000382288.3, OTTHUMP00000231891, ENST00000399351.7, OTTHUMT00000387822
    Conserved Domains (5) summary
    cd00204
    Location:15139
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:293429
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:23117
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:439
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1849
    ANK; ANK repeat [structural motif]
  2. NM_019028.2NP_061901.2  palmitoyltransferase ZDHHC13 isoform 1

    See identical proteins and their annotated locations for NP_061901.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB097014, BC056152
    Consensus CDS
    CCDS44550.1
    UniProtKB/Swiss-Prot
    Q8IUH4
    Related
    ENSP00000400113.2, OTTHUMP00000231890, ENST00000446113.6, OTTHUMT00000387821
    Conserved Domains (4) summary
    COG0666
    Location:145271
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:79192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:81112
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:423559
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    19117099..19176420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520195.1XP_011518497.1  palmitoyltransferase ZDHHC13 isoform X3

    See identical proteins and their annotated locations for XP_011518497.1

    UniProtKB/Swiss-Prot
    Q8IUH4
    Conserved Domains (5) summary
    cd00204
    Location:15139
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:293429
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:23117
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:439
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1849
    ANK; ANK repeat [structural motif]
  2. XM_005252996.2XP_005253053.1  palmitoyltransferase ZDHHC13 isoform X3

    See identical proteins and their annotated locations for XP_005253053.1

    UniProtKB/Swiss-Prot
    Q8IUH4
    Conserved Domains (5) summary
    cd00204
    Location:15139
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:293429
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:23117
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:439
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1849
    ANK; ANK repeat [structural motif]
  3. XM_011520194.2XP_011518496.1  palmitoyltransferase ZDHHC13 isoform X2

    Conserved Domains (7) summary
    cd00204
    Location:99212
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:443513
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:106199
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:222277
    Ank_5; Ankyrin repeats (many copies)
    pfam13900
    Location:220
    GVQW; Putative domain of unknown function
    sd00045
    Location:101132
    ANK; ANK repeat [structural motif]
    cl00337
    Location:347410
    PT_UbiA; UbiA family of prenyltransferases (PTases)
  4. XM_011520193.1XP_011518495.1  palmitoyltransferase ZDHHC13 isoform X1

    Conserved Domains (6) summary
    cd00204
    Location:15139
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01529
    Location:293401
    zf-DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:23117
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:439
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:1849
    ANK; ANK repeat [structural motif]
    cl19890
    Location:211338
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. XR_930875.2 RNA Sequence

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