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UGT2B28 UDP glucuronosyltransferase family 2 member B28 [ Homo sapiens (human) ]

Gene ID: 54490, updated on 2-Mar-2021

Summary

Official Symbol
UGT2B28provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B28provided by HGNC
Primary source
HGNC:HGNC:13479
See related
Ensembl:ENSG00000135226 MIM:606497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]
Expression
Biased expression in gall bladder (RPKM 10.0) and salivary gland (RPKM 0.9) See more
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Genomic context

See UGT2B28 in Genome Data Viewer
Location:
4q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (69280429..69295050)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70146193..70160768)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377267 Neighboring gene UDP glucuronosyltransferase family 2 member B11 Neighboring gene UDP glucuronosyltransferase family 2 member B4 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2B28
Names
UDP glucuronosyltransferase 2 family, polypeptide B28
UDP glycosyltransferase 2 family, polypeptide B28
UDPGT 2B28
NP_001193933.1
NP_444267.1
XP_016863792.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029527.1 RefSeqGene

    Range
    4977..19552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207004.2NP_001193933.1  UDP-glucuronosyltransferase 2B28 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two coding exons compared to variant 1, that causes a frameshift.The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC114786, AF177273
    Consensus CDS
    CCDS56330.1
    UniProtKB/Swiss-Prot
    Q9BY64
    Related
    ENSP00000427399.1, ENST00000511240.1
    Conserved Domains (2) summary
    pfam00201
    Location:24335
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl10013
    Location:26333
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  2. NM_053039.2NP_444267.1  UDP-glucuronosyltransferase 2B28 isoform 1 precursor

    See identical proteins and their annotated locations for NP_444267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC114786, AF177272
    Consensus CDS
    CCDS3528.1
    UniProtKB/Swiss-Prot
    Q9BY64
    Related
    ENSP00000334276.5, ENST00000335568.10
    Conserved Domains (2) summary
    PHA03392
    Location:269506
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:24525
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    69280429..69295050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008303.1XP_016863792.1  UDP-glucuronosyltransferase 2B28 isoform X1

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