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Mkrn1 makorin, ring finger protein, 1 [ Mus musculus (house mouse) ]

Gene ID: 54484, updated on 4-Nov-2022

Summary

Official Symbol
Mkrn1provided by MGI
Official Full Name
makorin, ring finger protein, 1provided by MGI
Primary source
MGI:MGI:1859353
See related
Ensembl:ENSMUSG00000029922 AllianceGenome:MGI:1859353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RFP
Summary
Enables chromatin binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is expressed in early conceptus and genitourinary system. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 72.2), liver E14.5 (RPKM 30.0) and 27 other tissues See more
Orthologs
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Genomic context

See Mkrn1 in Genome Data Viewer
Location:
6; 6 B1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39374738..39400480, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39397804..39423299, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 3 Neighboring gene RAB19, member RAS oncogene family Neighboring gene predicted gene 10244 Neighboring gene predicted gene, 25402 Neighboring gene DENN domain containing 2A Neighboring gene predicted gene, 52860 Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase makorin-1
Names
RING-type E3 ubiquitin transferase makorin-1
NP_001298038.1
NP_061280.2
XP_011239713.1
XP_011239714.1
XP_011239715.1
XP_017177172.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311109.2NP_001298038.1  E3 ubiquitin-protein ligase makorin-1 isoform 2

    See identical proteins and their annotated locations for NP_001298038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 2.
    Source sequence(s)
    AC153624
    Consensus CDS
    CCDS80528.1
    UniProtKB/TrEMBL
    E9QAG7, Q8C5V4
    Related
    ENSMUSP00000110471.2, ENSMUST00000114823.8
    Conserved Domains (4) summary
    PHA03096
    Location:157306
    PHA03096; p28-like protein; Provisional
    cd16730
    Location:214274
    RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
    pfam15815
    Location:336415
    MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
    pfam18345
    Location:2644
    zf_CCCH_4; Zinc finger domain
  2. NM_001411235.1NP_001398164.1  E3 ubiquitin-protein ligase makorin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153624
  3. NM_001411236.1NP_001398165.1  E3 ubiquitin-protein ligase makorin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    E9QAG7
  4. NM_001411237.1NP_001398166.1  E3 ubiquitin-protein ligase makorin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    E9QAG7
  5. NM_001411238.1NP_001398167.1  E3 ubiquitin-protein ligase makorin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    E9QAG7
  6. NM_001411239.1NP_001398168.1  E3 ubiquitin-protein ligase makorin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    E9QAG7
  7. NM_001411240.1NP_001398169.1  E3 ubiquitin-protein ligase makorin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153624
  8. NM_001411241.1NP_001398170.1  E3 ubiquitin-protein ligase makorin-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    Q99LD7
  9. NM_001411242.1NP_001398171.1  E3 ubiquitin-protein ligase makorin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    Q9DB86
  10. NM_001411243.1NP_001398172.1  E3 ubiquitin-protein ligase makorin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    Q9DB86
  11. NM_001411244.1NP_001398173.1  E3 ubiquitin-protein ligase makorin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    Q9DB86
  12. NM_001411245.1NP_001398174.1  E3 ubiquitin-protein ligase makorin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153624
    UniProtKB/TrEMBL
    Q9DB86
  13. NM_001411246.1NP_001398175.1  E3 ubiquitin-protein ligase makorin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC153624
  14. NM_001411247.1NP_001398176.1  E3 ubiquitin-protein ligase makorin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC153624
  15. NM_001411248.1NP_001398177.1  E3 ubiquitin-protein ligase makorin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC153624
  16. NM_018810.3NP_061280.2  E3 ubiquitin-protein ligase makorin-1 isoform 1

    See identical proteins and their annotated locations for NP_061280.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153624
    Consensus CDS
    CCDS20022.1
    UniProtKB/TrEMBL
    Q8C5V4
    Related
    ENSMUSP00000031985.7, ENSMUST00000031985.13
    Conserved Domains (5) summary
    PHA03096
    Location:221370
    PHA03096; p28-like protein; Provisional
    cd16730
    Location:278338
    RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
    pfam15815
    Location:400479
    MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
    pfam18044
    Location:5980
    zf-CCCH_4; CCCH-type zinc finger
    pfam18345
    Location:90108
    zf_CCCH_4; Zinc finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39374738..39400480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321683.2XP_017177172.1  E3 ubiquitin-protein ligase makorin-1 isoform X1

    UniProtKB/TrEMBL
    Q8C5V4
    Conserved Domains (5) summary
    PHA03096
    Location:221370
    PHA03096; p28-like protein; Provisional
    cd16730
    Location:278338
    RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
    pfam15815
    Location:400479
    MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
    pfam18044
    Location:5980
    zf-CCCH_4; CCCH-type zinc finger
    pfam18345
    Location:90108
    zf_CCCH_4; Zinc finger domain
  2. XM_011241412.4XP_011239714.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

    UniProtKB/TrEMBL
    E9QAG7
    Conserved Domains (4) summary
    PHA03096
    Location:157306
    PHA03096; p28-like protein; Provisional
    cd16730
    Location:214274
    RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
    pfam15815
    Location:336415
    MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
    pfam18345
    Location:2644
    zf_CCCH_4; Zinc finger domain
  3. XM_011241411.4XP_011239713.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

    UniProtKB/TrEMBL
    E9QAG7
    Conserved Domains (4) summary
    PHA03096
    Location:157306
    PHA03096; p28-like protein; Provisional
    cd16730
    Location:214274
    RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
    pfam15815
    Location:336415
    MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
    pfam18345
    Location:2644
    zf_CCCH_4; Zinc finger domain
  4. XM_011241413.4XP_011239715.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

    UniProtKB/TrEMBL
    E9QAG7
    Conserved Domains (4) summary
    PHA03096
    Location:157306
    PHA03096; p28-like protein; Provisional
    cd16730
    Location:214274
    RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
    pfam15815
    Location:336415
    MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
    pfam18345
    Location:2644
    zf_CCCH_4; Zinc finger domain