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TRMT13 tRNA methyltransferase 13 homolog [ Homo sapiens (human) ]

Gene ID: 54482, updated on 23-Nov-2021

Summary

Official Symbol
TRMT13provided by HGNC
Official Full Name
tRNA methyltransferase 13 homologprovided by HGNC
Primary source
HGNC:HGNC:25502
See related
Ensembl:ENSG00000122435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC76
Expression
Ubiquitous expression in lymph node (RPKM 6.2), appendix (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

See TRMT13 in Genome Data Viewer
Location:
1p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (100133132..100150496)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (100598706..100616054)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A3 Neighboring gene RNA, U6 small nuclear 1318, pseudogene Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene SAS-6 centriolar assembly protein Neighboring gene leucine rich repeat containing 39 Neighboring gene ribosomal protein L23a pseudogene 90 Neighboring gene dihydrolipoamide branched chain transacylase E2 Neighboring gene brain protein I3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10287, FLJ11219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA 2'-O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA:m(4)X modification enzyme TRM13 homolog
Names
coiled-coil domain containing 76
coiled-coil domain-containing protein 76
tRNA [Gm4] methyltransferase
tRNA guanosine-2'-O-methyltransferase TRM13 homolog
NP_001380338.1
NP_001380339.1
NP_001380340.1
NP_001380341.1
NP_001380342.1
NP_001380343.1
NP_061956.2
XP_005271003.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393409.1NP_001380338.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL445928
    Conserved Domains (3) summary
    pfam05206
    Location:151455
    TRM13; Methyltransferase TRM13
    pfam05253
    Location:5980
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:1745
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein
  2. NM_001393410.1NP_001380339.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL445928
    Conserved Domains (2) summary
    pfam05206
    Location:127431
    TRM13; Methyltransferase TRM13
    pfam11722
    Location:1745
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein
  3. NM_001393411.1NP_001380340.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL445928
    Conserved Domains (3) summary
    pfam05253
    Location:5980
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:1745
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein
    cl17173
    Location:165273
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. NM_001393412.1NP_001380341.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL445928
    Conserved Domains (3) summary
    pfam05253
    Location:5980
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:1745
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein
    cl17173
    Location:151259
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. NM_001393413.1NP_001380342.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL445928
    Conserved Domains (3) summary
    pfam05253
    Location:5980
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:1745
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein
    cl17173
    Location:165274
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. NM_001393414.1NP_001380343.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL445928
    Conserved Domains (3) summary
    pfam05253
    Location:5980
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:1745
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein
    cl17173
    Location:151260
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. NM_019083.3NP_061956.2  tRNA:m(4)X modification enzyme TRM13 homolog isoform 1

    See identical proteins and their annotated locations for NP_061956.2

    Status: VALIDATED

    Source sequence(s)
    AL445928
    Consensus CDS
    CCDS765.1
    UniProtKB/Swiss-Prot
    Q9NUP7
    Related
    ENSP00000359160.2, ENST00000370141.7
    Conserved Domains (3) summary
    pfam05206
    Location:165469
    TRM13; Methyltransferase TRM13
    pfam05253
    Location:5980
    zf-U11-48K; U11-48K-like CHHC zinc finger
    pfam11722
    Location:1745
    zf-TRM13_CCCH; CCCH zinc finger in TRM13 protein

RNA

  1. NR_135078.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK002081, AK298941, AL699548

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    100133132..100150496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270946.2XP_005271003.1  tRNA:m(4)X modification enzyme TRM13 homolog isoform X2

    Conserved Domains (1) summary
    pfam05206
    Location:24328
    TRM13; Methyltransferase TRM13

RNA

  1. XR_001737237.1 RNA Sequence

  2. XR_246276.3 RNA Sequence

  3. XR_001737241.1 RNA Sequence

  4. XR_002956838.1 RNA Sequence

  5. XR_001737239.1 RNA Sequence

  6. XR_001737238.1 RNA Sequence

  7. XR_001737240.1 RNA Sequence

  8. XR_246275.3 RNA Sequence

  9. XR_001737236.1 RNA Sequence

  10. XR_246273.4 RNA Sequence

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