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Tbc1d32 TBC1 domain family, member 32 [ Mus musculus (house mouse) ]

Gene ID: 544696, updated on 12-May-2024

Summary

Official Symbol
Tbc1d32provided by MGI
Official Full Name
TBC1 domain family, member 32provided by MGI
Primary source
MGI:MGI:2442827
See related
Ensembl:ENSMUSG00000038122 AllianceGenome:MGI:2442827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bromi; C6orf170; b2b2284Clo; D630037F22Rik
Summary
Acts upstream of or within several processes, including animal organ development; non-motile cilium assembly; and smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in cilium and cytoplasm. Used to study Bardet-Biedl syndrome; Meckel syndrome; VACTERL association; and visceral heterotaxy. Orthologous to human TBC1D32 (TBC1 domain family member 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 1.5), CNS E18 (RPKM 1.1) and 26 other tissues See more
Orthologs
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Genomic context

See Tbc1d32 in Genome Data Viewer
Location:
10 B3; 10 28.45 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (55890389..56106495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (56014293..56228968, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31849 Neighboring gene putative heat shock protein HSP 90-beta-3 Neighboring gene STARR-seq mESC enhancer starr_26716 Neighboring gene STARR-seq mESC enhancer starr_26717 Neighboring gene STARR-seq mESC enhancer starr_26718 Neighboring gene STARR-seq mESC enhancer starr_26719 Neighboring gene STARR-seq mESC enhancer starr_26720 Neighboring gene STARR-seq mESC enhancer starr_26721 Neighboring gene STARR-seq mESC enhancer starr_26722 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55826518-55826701 Neighboring gene UPF0183 protein C16orf70 homolog Neighboring gene MSL3 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55948756-55948865 Neighboring gene STARR-seq mESC enhancer starr_26724 Neighboring gene STARR-seq mESC enhancer starr_26725 Neighboring gene STARR-seq mESC enhancer starr_26726 Neighboring gene STARR-seq mESC enhancer starr_26730 Neighboring gene STARR-seq mESC enhancer starr_26731 Neighboring gene STARR-seq mESC enhancer starr_26732 Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene gap junction protein, alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (4)  1 citation
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axoneme assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube patterning IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway involved in dorsal/ventral neural tube patterning IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033385.3NP_001028557.2  protein broad-minded

    See identical proteins and their annotated locations for NP_001028557.2

    Status: VALIDATED

    Source sequence(s)
    AC155829, AK035346, AK141206, BP761946, BY341016, CJ182214, CN536044, CN536606, CR756627, CR757357
    Consensus CDS
    CCDS48562.1
    UniProtKB/Swiss-Prot
    Q3URV1
    Related
    ENSMUSP00000097328.4, ENSMUST00000099739.5
    Conserved Domains (1) summary
    pfam14961
    Location:121293
    BROMI; Broad-minded protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    55890389..56106495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243191.4XP_011241493.1  protein broad-minded isoform X1

    Conserved Domains (1) summary
    pfam14961
    Location:121033
    BROMI; Broad-minded protein
  2. XM_011243192.4XP_011241494.1  protein broad-minded isoform X2

    Conserved Domains (1) summary
    pfam14961
    Location:12857
    BROMI; Broad-minded protein