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Cfap74 cilia and flagella associated protein 74 [ Mus musculus (house mouse) ]

Gene ID: 544678, updated on 2-Nov-2024

Summary

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Official Symbol
Cfap74provided by MGI
Official Full Name
cilia and flagella associated protein 74provided by MGI
Primary source
MGI:MGI:1917130
See related
Ensembl:ENSMUSG00000078490 AllianceGenome:MGI:1917130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A530045M11; 2010015L04Rik
Summary
Predicted to be involved in axoneme assembly. Predicted to be located in axoneme; nucleus; and sperm flagellum. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CFAP74 (cilia and flagella associated protein 74). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 12.3), thymus adult (RPKM 2.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Cfap74 in Genome Data Viewer
Location:
4 E2; 4 86.17 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155493647..155551280)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155392099..155466823)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12256 Neighboring gene protein kinase C, zeta Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit delta Neighboring gene STARR-positive B cell enhancer ABC_E4738 Neighboring gene STARR-seq mESC enhancer starr_12263 Neighboring gene transmembrane protein 52 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene guanine nucleotide binding protein (G protein), beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA1751

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cilia- and flagella-associated protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166029.1 → NP_001159501.1  cilia- and flagella-associated protein 74 isoform 2

    See identical proteins and their annotated locations for NP_001159501.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the presence and absence of exons in its 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (2) with a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC056495, CD776645, CJ049960
    Consensus CDS
    CCDS51402.1
    UniProtKB/TrEMBL
    G3UWF6
    Related
    ENSMUSP00000131899.2, ENSMUST00000123952.9

  2. NM_001368738.1 → NP_001355667.1  cilia- and flagella-associated protein 74 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670227
    Consensus CDS
    CCDS89870.1
    UniProtKB/TrEMBL
    A0A571BED3, A0A571BG73
    Related
    ENSMUSP00000158718.2, ENSMUST00000238423.2
    Conserved Domains (1) summary
    PTZ00121
    Location:33 → 374
    PTZ00121; MAEBL; Provisional

  3. NM_177674.5 → NP_808342.3  cilia- and flagella-associated protein 74 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK134858, AL670227, CJ049960
    UniProtKB/Swiss-Prot
    Q3UY96
    Related
    ENSMUST00000094408.10
    Conserved Domains (1) summary
    PTZ00121
    Location:33 → 374
    PTZ00121; MAEBL; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155493647..155551280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164244.1 → XP_036020137.1  cilia- and flagella-associated protein 74 isoform X2

    UniProtKB/Swiss-Prot
    A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
    Conserved Domains (1) summary
    pfam17380
    Location:93 → 418
    DUF5401; Family of unknown function (DUF5401)

  2. XM_036164243.1 → XP_036020136.1  cilia- and flagella-associated protein 74 isoform X1

    UniProtKB/Swiss-Prot
    A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
    Conserved Domains (1) summary
    pfam17380
    Location:93 → 418
    DUF5401; Family of unknown function (DUF5401)

  3. XM_036164242.1 → XP_036020135.1  cilia- and flagella-associated protein 74 isoform X1

    UniProtKB/Swiss-Prot
    A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
    Conserved Domains (1) summary
    pfam17380
    Location:93 → 418
    DUF5401; Family of unknown function (DUF5401)

  4. XM_036164245.1 → XP_036020138.1  cilia- and flagella-associated protein 74 isoform X3

    UniProtKB/Swiss-Prot
    A2AD78, A4QMY6, F6VQ96, Q14DK1, Q3UY96, Q8BI90
    Conserved Domains (1) summary
    pfam17380
    Location:93 → 418
    DUF5401; Family of unknown function (DUF5401)

  5. XM_036164246.1 → XP_036020139.1  cilia- and flagella-associated protein 74 isoform X4

    Conserved Domains (1) summary
    PTZ00121
    Location:33 → 374
    PTZ00121; MAEBL; Provisional

  6. XM_006539054.4 → XP_006539117.1  cilia- and flagella-associated protein 74 isoform X6

    Conserved Domains (1) summary
    PTZ00121
    Location:33 → 374
    PTZ00121; MAEBL; Provisional

  7. XM_006539053.4 → XP_006539116.1  cilia- and flagella-associated protein 74 isoform X5

    Conserved Domains (1) summary
    PTZ00121
    Location:33 → 374
    PTZ00121; MAEBL; Provisional

  8. XM_011250302.3 → XP_011248604.1  cilia- and flagella-associated protein 74 isoform X8

    Conserved Domains (1) summary
    PTZ00121
    Location:33 → 374
    PTZ00121; MAEBL; Provisional

  9. XM_036164247.1 → XP_036020140.1  cilia- and flagella-associated protein 74 isoform X7

    Conserved Domains (1) summary
    PTZ00121
    Location:33 → 374
    PTZ00121; MAEBL; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UY96.3 GenPept UniProtKB/Swiss-Prot:Q3UY96

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