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TAF7L TATA-box binding protein associated factor 7 like [ Homo sapiens (human) ]

Gene ID: 54457, updated on 4-Oct-2020

Summary

Official Symbol
TAF7Lprovided by HGNC
Official Full Name
TATA-box binding protein associated factor 7 likeprovided by HGNC
Primary source
HGNC:HGNC:11548
See related
Ensembl:ENSG00000102387 MIM:300314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT40; TAF2Q
Summary
This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Restricted expression toward testis (RPKM 16.4) See more
Orthologs

Genomic context

See TAF7L in Genome Data Viewer
Location:
Xq22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (101268257..101293083, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100523241..100548059, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene YWHAQ pseudogene 8 Neighboring gene dystrophin related protein 2 Neighboring gene RNA, U6 small nuclear 934, pseudogene Neighboring gene NANOGNB pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 7-like
Names
RNA polymerase II TBP-associated factor subunit Q
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TATA box-binding protein-associated factor 50 kDa
TBP-associated factor, RNA polymerase II, Q
cancer/testis antigen 40
transcription initiation factor TFIID 50 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016220.1 RefSeqGene

    Range
    4989..29815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168474.2NP_001161946.1  transcription initiation factor TFIID subunit 7-like isoform 2

    See identical proteins and their annotated locations for NP_001161946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF285595, BC043391
    Consensus CDS
    CCDS55466.1
    UniProtKB/Swiss-Prot
    Q5H9L4
    Related
    ENSP00000349235.1, ENST00000356784.1
    Conserved Domains (1) summary
    pfam04658
    Location:12190
    TAFII55_N; TAFII55 protein conserved region
  2. NM_024885.4NP_079161.3  transcription initiation factor TFIID subunit 7-like isoform 1

    See identical proteins and their annotated locations for NP_079161.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL109801, BC043391, DB455298
    Consensus CDS
    CCDS35347.1
    UniProtKB/Swiss-Prot
    Q5H9L4
    Related
    ENSP00000361998.3, ENST00000372907.7
    Conserved Domains (1) summary
    pfam04658
    Location:98276
    TAFII55_N; TAFII55 protein conserved region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    101268257..101293083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724664.1XP_006724727.1  transcription initiation factor TFIID subunit 7-like isoform X1

    Conserved Domains (1) summary
    pfam04658
    Location:98276
    TAFII55_N; TAFII55 protein conserved region
  2. XM_005262152.1XP_005262209.1  transcription initiation factor TFIID subunit 7-like isoform X2

    See identical proteins and their annotated locations for XP_005262209.1

    Conserved Domains (1) summary
    pfam04658
    Location:12190
    TAFII55_N; TAFII55 protein conserved region
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