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Nfat5 nuclear factor of activated T cells 5 [ Mus musculus (house mouse) ]

Gene ID: 54446, updated on 12-May-2024

Summary

Official Symbol
Nfat5provided by MGI
Official Full Name
nuclear factor of activated T cells 5provided by MGI
Primary source
MGI:MGI:1859333
See related
Ensembl:ENSMUSG00000003847 AllianceGenome:MGI:1859333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAG-8; CAG80; OREBP; nfatz; NFATL1; TonEBP; mKIAA0827; B130038B15Rik
Summary
Enables DNA binding activity. Acts upstream of or within positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; and regulation of calcineurin-NFAT signaling cascade. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; endocrine gland; genitourinary system; and midbrain roof plate. Orthologous to human NFAT5 (nuclear factor of activated T cells 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.9), bladder adult (RPKM 16.6) and 28 other tissues See more
Orthologs
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Genomic context

See Nfat5 in Genome Data Viewer
Location:
8 D3; 8 53.93 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108020072..108106149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107293435..107379517)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930517G24 gene Neighboring gene STARR-seq mESC enhancer starr_22599 Neighboring gene ribosomal protein S18, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_22600 Neighboring gene STARR-positive B cell enhancer ABC_E9742 Neighboring gene predicted gene, 51546 Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene NIN1/RPN12 binding protein 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in R-loop processing ISO
Inferred from Sequence Orthology
more info
 
involved_in calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of urine volume TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of renal water homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in response to water deprivation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
nuclear factor of activated T-cells 5
Names
T-cell transcription factor NFAT5
rel domain-containing transcription factor NFAT5
tonicity-responsive enhancer binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286260.1NP_001273189.1  nuclear factor of activated T-cells 5 isoform c

    See identical proteins and their annotated locations for NP_001273189.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) uses an alternate splice site and lacks a portion of the 3' coding region, compared to variant b. This results in a shorter protein (isoform c) with a distinct C-terminus, compared to variant b.
    Source sequence(s)
    AC158364, AK052632, AK134022, BE633760
    Consensus CDS
    CCDS72168.1
    UniProtKB/Swiss-Prot
    Q9WV30
    UniProtKB/TrEMBL
    Q3UZ77
    Related
    ENSMUSP00000075311.5, ENSMUST00000075922.11
    Conserved Domains (2) summary
    cd07882
    Location:280440
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:444543
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  2. NM_018823.2NP_061293.2  nuclear factor of activated T-cells 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) encodes the longest isoform (b).
    Source sequence(s)
    AC158364, AF200687, AF369980, AK045123, BE633760
    Consensus CDS
    CCDS22648.2
    UniProtKB/TrEMBL
    Q8VHJ6
    Related
    ENSMUSP00000127784.2, ENSMUST00000169453.8
    Conserved Domains (2) summary
    cd07882
    Location:298458
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:462561
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  3. NM_133957.3NP_598718.2  nuclear factor of activated T-cells 5 isoform a

    See identical proteins and their annotated locations for NP_598718.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. This results in a protein (isoform a) with a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    AC158364, AF200687, AF369980, AK045123, BE633760
    Consensus CDS
    CCDS40464.1
    UniProtKB/TrEMBL
    A0A1U6URG8, Q8VHJ6
    Conserved Domains (3) summary
    cd07882
    Location:204364
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:368467
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:11241365
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    108020072..108106149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531192.4XP_006531255.1  nuclear factor of activated T-cells 5 isoform X2

    See identical proteins and their annotated locations for XP_006531255.1

    UniProtKB/Swiss-Prot
    E9Q0P3, E9Q6U2, G5E8N9, Q91WY0, Q9JLA1, Q9WV30
    UniProtKB/TrEMBL
    Q8VHJ6
    Related
    ENSMUSP00000116094.2, ENSMUST00000125721.8
    Conserved Domains (3) summary
    cd07882
    Location:280440
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:444543
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:12001441
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. XM_030243679.1XP_030099539.1  nuclear factor of activated T-cells 5 isoform X3

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (3) summary
    cd07882
    Location:280440
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:444543
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:11991440
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. XM_030243680.1XP_030099540.1  nuclear factor of activated T-cells 5 isoform X5

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (3) summary
    cd07882
    Location:233393
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:397496
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:11531394
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  4. XM_030243681.2XP_030099541.1  nuclear factor of activated T-cells 5 isoform X6

    UniProtKB/TrEMBL
    A0A1U6URG8, Q8VHJ6
    Related
    ENSMUSP00000076653.7, ENSMUST00000077440.13
    Conserved Domains (3) summary
    cd07882
    Location:204364
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:368467
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:11241365
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  5. XM_006531191.4XP_006531254.1  nuclear factor of activated T-cells 5 isoform X1

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (3) summary
    cd07882
    Location:298458
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:462561
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:12171458
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. XM_006531193.4XP_006531256.1  nuclear factor of activated T-cells 5 isoform X4

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (3) summary
    cd07882
    Location:251411
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:415514
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:11711412
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  7. XM_036154180.1XP_036010073.1  nuclear factor of activated T-cells 5 isoform X7

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:204364
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:368467
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  8. XM_036154184.1XP_036010077.1  nuclear factor of activated T-cells 5 isoform X11

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:56216
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:220319
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  9. XM_006531194.3XP_006531257.1  nuclear factor of activated T-cells 5 isoform X8

    See identical proteins and their annotated locations for XP_006531257.1

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:98258
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:262361
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  10. XM_006531196.3XP_006531259.1  nuclear factor of activated T-cells 5 isoform X9

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:74234
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:238337
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  11. XM_030243682.2XP_030099542.1  nuclear factor of activated T-cells 5 isoform X8

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:98258
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:262361
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  12. XM_036154182.1XP_036010075.1  nuclear factor of activated T-cells 5 isoform X9

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:74234
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:238337
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  13. XM_036154181.1XP_036010074.1  nuclear factor of activated T-cells 5 isoform X8

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:98258
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:262361
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  14. XM_036154183.1XP_036010076.1  nuclear factor of activated T-cells 5 isoform X10

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:74234
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:238337
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  15. XM_017312904.3XP_017168393.1  nuclear factor of activated T-cells 5 isoform X6

    UniProtKB/TrEMBL
    A0A1U6URG8, Q8VHJ6
    Conserved Domains (3) summary
    cd07882
    Location:204364
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:368467
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    pfam09606
    Location:11241365
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  16. XM_017312905.3XP_017168394.1  nuclear factor of activated T-cells 5 isoform X8

    UniProtKB/TrEMBL
    Q8VHJ6
    Conserved Domains (2) summary
    cd07882
    Location:98258
    RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)
    cd01178
    Location:262361
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.