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Unc93b1 unc-93 homolog B1, TLR signaling regulator [ Mus musculus (house mouse) ]

Gene ID: 54445, updated on 12-Aug-2019

Summary

Official Symbol
Unc93b1provided by MGI
Official Full Name
unc-93 homolog B1, TLR signaling regulatorprovided by MGI
Primary source
MGI:MGI:1859307
See related
Ensembl:ENSMUSG00000036908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc93b; Unc-93B1
Expression
Broad expression in spleen adult (RPKM 325.1), mammary gland adult (RPKM 128.7) and 15 other tissues See more
Orthologs

Genomic context

See Unc93b1 in Genome Data Viewer
Location:
19; 19 A
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3935158..3949340)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (3935186..3949340)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene predicted gene, 42059 Neighboring gene predicted gene, 29846 Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene uncharacterized LOC115489017

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Toll-like receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Toll-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor 3 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
toll-like receptor 7 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 7 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor 7 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
toll-like receptor 9 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor 9 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein unc-93 homolog B1
Names
unc-93 homolog B
unc-93 homolog B1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161428.1NP_001154900.1  protein unc-93 homolog B1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI462917, AK162535, AK165060, BY199008
    Consensus CDS
    CCDS50346.1
    UniProtKB/Swiss-Prot
    Q8VCW4
    UniProtKB/TrEMBL
    E9Q8P6
    Related
    ENSMUSP00000128751.1, ENSMUST00000165711.2
    Conserved Domains (1) summary
    cl21472
    Location:145210
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. NM_019449.2NP_062322.2  protein unc-93 homolog B1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
    Source sequence(s)
    AI462917, AK165060, BY199008
    Consensus CDS
    CCDS29404.2
    UniProtKB/Swiss-Prot
    Q8VCW4
    UniProtKB/TrEMBL
    E9PYK0
    Related
    ENSMUSP00000124272.1, ENSMUST00000162708.6
    Conserved Domains (1) summary
    cl21472
    Location:145210
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p6 C57BL/6J

    Range
    3935158..3949340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531798.2XP_006531861.1  protein unc-93 homolog B1 isoform X1

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