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Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 [ Mus musculus (house mouse) ]

Gene ID: 54405, updated on 2-Apr-2024

Summary

Official Symbol
Ndufa1provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit A1provided by MGI
Primary source
MGI:MGI:1929511
See related
Ensembl:ENSMUSG00000016427 AllianceGenome:MGI:1929511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MWFE; 1810049F12Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; cranium; respiratory system; and sensory organ. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 12. Orthologous to human NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 199.1), kidney adult (RPKM 150.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
X A3.3; X 21.61 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36451241..36454891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37187588..37191238, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene UPF3 regulator of nonsense transcripts homolog B (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E5721 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34666661-34666844 Neighboring gene NFKB activating protein Neighboring gene A kinase anchor protein 14 Neighboring gene predicted gene, 39503 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34731294-34731403 Neighboring gene ring finger protein 113A1 Neighboring gene predicted gene 9 Neighboring gene reproductive homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Names
CI-MWFE
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE)
NADH dehydrogenase 1 alpha subcomplex, 1
NADH ubiquinone oxidoreductase subunit MWFE
NADH-ubiquinone oxidoreductase MWFE subunit
complex I-MWFE
NP_062316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019443.2NP_062316.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

    See identical proteins and their annotated locations for NP_062316.1

    Status: VALIDATED

    Source sequence(s)
    AI844651, AK007840, CF383819
    Consensus CDS
    CCDS40928.1
    UniProtKB/Swiss-Prot
    O35683
    UniProtKB/TrEMBL
    Q545K0
    Related
    ENSMUSP00000016571.8, ENSMUST00000016571.8
    Conserved Domains (1) summary
    pfam15879
    Location:256
    MWFE; NADH-ubiquinone oxidoreductase MWFE subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36451241..36454891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)