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Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 [ Mus musculus (house mouse) ]

Gene ID: 54393, updated on 8-Jan-2023

Summary

Official Symbol
Gabbr1provided by MGI
Official Full Name
gamma-aminobutyric acid (GABA) B receptor, 1provided by MGI
Primary source
MGI:MGI:1860139
See related
Ensembl:ENSMUSG00000024462 AllianceGenome:MGI:1860139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GABAB1; GABAbR1; bM573K1.1
Summary
Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Located in several cellular components, including GABA-ergic synapse; Schaffer collateral - CA1 synapse; and synaptic membrane. Part of G protein-coupled receptor dimeric complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 73.7), frontal lobe adult (RPKM 72.2) and 20 other tissues See more
Orthologs
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Genomic context

See Gabbr1 in Genome Data Viewer
Location:
17 B1; 17 19.16 cM
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37356858..37385197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (37045966..37074305)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 5 Neighboring gene zinc finger protein 57 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene predicted gene, 41579 Neighboring gene olfactory receptor family 2 subfamily H member 2 Neighboring gene olfactory receptor family 2 subfamily H member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled GABA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to G protein-coupled GABA receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled GABA receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential NAS
Non-traceable Author Statement
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway EXP
Inferred from Experiment
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic EXP
Inferred from Experiment
more info
PubMed 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron-glial cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, GABAergic NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of G protein-coupled GABA receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of G protein-coupled receptor dimeric complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of G protein-coupled receptor heterodimeric complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of G protein-coupled receptor heterodimeric complex ISO
Inferred from Sequence Orthology
more info
 
part_of GABA receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in GABA-ergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-aminobutyric acid type B receptor subunit 1
Names
GABA-B receptor 1
GABA-B-R1
GABA-BR1
GABA-BR1b receptor
bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)
gb1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413996.1NP_001400925.1  gamma-aminobutyric acid type B receptor subunit 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116130, CR974567
  2. NM_001413997.1NP_001400926.1  gamma-aminobutyric acid type B receptor subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116130, CR974567
  3. NM_019439.4NP_062312.3  gamma-aminobutyric acid type B receptor subunit 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062312.3

    Status: VALIDATED

    Source sequence(s)
    AC116130, CR974567
    Consensus CDS
    CCDS37616.1
    UniProtKB/Swiss-Prot
    Q9WV17, Q9WV18
    Related
    ENSMUSP00000025338.10, ENSMUST00000025338.16
    Conserved Domains (5) summary
    cd06366
    Location:170562
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:602856
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam00084
    Location:106156
    Sushi; Sushi repeat (SCR repeat)
    pfam01094
    Location:186542
    ANF_receptor; Receptor family ligand binding region
    pfam10211
    Location:884926
    Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37356858..37385197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524632.3XP_006524695.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

    Conserved Domains (4) summary
    cd00033
    Location:105157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd15291
    Location:582854
    7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam10211
    Location:877919
    Ax_dynein_light; Axonemal dynein light chain
    cd06366
    Location:163562
    PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
  2. XM_030249909.1XP_030105769.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

    Conserved Domains (3) summary
    cd15291
    Location:413685
    7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam10211
    Location:708750
    Ax_dynein_light; Axonemal dynein light chain
    cd06366
    Location:2393
    PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
  3. XM_030249908.1XP_030105768.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

    Related
    ENSMUSP00000134268.2, ENSMUST00000172792.8
    Conserved Domains (3) summary
    cd15291
    Location:473745
    7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam10211
    Location:768810
    Ax_dynein_light; Axonemal dynein light chain
    cd06366
    Location:54453
    PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

RNA

  1. XR_001782091.3 RNA Sequence

    Related
    ENSMUST00000173823.8