Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gabbr1provided by MGI
Official Full Name: gamma-aminobutyric acid (GABA) B receptor, 1provided by MGI
Primary source: MGI:MGI:1860139
See related: Ensembl:ENSMUSG00000024462 AllianceGenome:MGI:1860139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GABAB1; GABAbR1; bM573K1.1
Summary: Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Located in several cellular components, including GABA-ergic synapse; Schaffer collateral - CA1 synapse; and synaptic membrane. Part of G protein-coupled receptor dimeric complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 73.7), frontal lobe adult (RPKM 72.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 19.16 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (37356858..37385197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (37045966..37074305)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Medial prefrontal cortex Notch1 signalling mediates methamphetamine-induced psychosis via Hes1-dependent suppression of GABAB1 receptor expression.
Title: Medial prefrontal cortex Notch1 signalling mediates methamphetamine-induced psychosis via Hes1-dependent suppression of GABAB1 receptor expression.
GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice.
Title: GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice.
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease.
Title: Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease.
GABAB receptors blockage modulates somatic and aversive manifestations induced by nicotine withdrawal.
Title: GABAB receptors blockage modulates somatic and aversive manifestations induced by nicotine withdrawal.
Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer's disease.
Title: Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer's disease.
The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells.
Title: The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells.
Reelin signaling modulates GABAB receptor function in the neocortex.
Title: Reelin signaling modulates GABAB receptor function in the neocortex.
Role of leptin in the regulation of food intake in fasted mice.
Title: Role of leptin in the regulation of food intake in fasted mice.
Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior.
Title: Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior.
GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.
Title: GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (10) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gabbr1 (e-PCR), detects polymorphism
- UniSTS:525645

NoName (e-PCR)
- UniSTS:237645

UniSTS:496042 (e-PCR)
- UniSTS:496042

Gabbr1 (e-PCR), detects polymorphism
- UniSTS:496042

573K1T (e-PCR), detects polymorphism
- UniSTS:140975

RH135914 (e-PCR)
- UniSTS:209912

Homology

Homologs of the Gabbr1 gene: The Gabbr1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 382 organisms have orthologs with human gene Gabbr1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled GABA receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to G protein-coupled GABA receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled GABA receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables extracellular matrix protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission, postsynaptic	EXP Inferred from Experiment more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuron-glial cell signaling	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled GABA receptor complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor dimeric complex	IDA Inferred from Direct Assay more info	PubMed
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of G protein-coupled receptor heterodimeric complex	ISO Inferred from Sequence Orthology more info
part_of GABA receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-aminobutyric acid type B receptor subunit 1

Names: GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABA-BR1b receptor; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); gb1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413996.1 → NP_001400925.1 gamma-aminobutyric acid type B receptor subunit 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC116130, CR974567
NM_001413997.1 → NP_001400926.1 gamma-aminobutyric acid type B receptor subunit 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC116130, CR974567
NM_019439.4 → NP_062312.3 gamma-aminobutyric acid type B receptor subunit 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_062312.3

Status: VALIDATED

Source sequence(s)

AC116130, CR974567

Consensus CDS

CCDS37616.1

UniProtKB/Swiss-Prot

Q9WV17, Q9WV18

Related

ENSMUSP00000025338.10, ENSMUST00000025338.16

Conserved Domains (5) summary

cd06366
Location:170 → 562

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:602 → 856

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam00084
Location:106 → 156

Sushi; Sushi repeat (SCR repeat)

pfam01094
Location:186 → 542

ANF_receptor; Receptor family ligand binding region

pfam10211
Location:884 → 926

Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

37356858..37385197

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524632.3 → XP_006524695.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

Conserved Domains (4) summary

cd00033
Location:105 → 157

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd15291
Location:582 → 854

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam10211
Location:877 → 919

Ax_dynein_light; Axonemal dynein light chain

cd06366
Location:163 → 562

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
XM_030249909.1 → XP_030105769.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3

Conserved Domains (3) summary

cd15291
Location:413 → 685

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam10211
Location:708 → 750

Ax_dynein_light; Axonemal dynein light chain

cd06366
Location:2 → 393

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
XM_030249908.1 → XP_030105768.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2

Related

ENSMUSP00000134268.2, ENSMUST00000172792.8

Conserved Domains (3) summary

cd15291
Location:473 → 745

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam10211
Location:768 → 810

Ax_dynein_light; Axonemal dynein light chain

cd06366
Location:54 → 453

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)