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Azin1 antizyme inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 54375, updated on 7-Feb-2023

Summary

Official Symbol
Azin1provided by MGI
Official Full Name
antizyme inhibitor 1provided by MGI
Primary source
MGI:MGI:1859169
See related
Ensembl:ENSMUSG00000037458 AllianceGenome:MGI:1859169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AZI; Oazi; Oazin; 1700085L02Rik
Summary
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in small intestine adult (RPKM 42.0), duodenum adult (RPKM 41.1) and 28 other tissues See more
Orthologs
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Genomic context

See Azin1 in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (38487674..38523506, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (38487430..38519294, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA G930009F23 gene Neighboring gene predicted gene, 41308 Neighboring gene microRNA 6951 Neighboring gene RIKEN cDNA 2310043O21 gene Neighboring gene predicted gene, 41309 Neighboring gene siah E3 ubiquitin protein ligase 1, pseudogene 2 Neighboring gene predicted gene, 29697 Neighboring gene RIKEN cDNA 1100001I12 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables ornithine decarboxylase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ornithine decarboxylase activator activity IGI
Inferred from Genetic Interaction
more info
 
enables ornithine decarboxylase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ornithine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
antizyme inhibitor 1
Names
ODC antizyme inhibitor
ornithine decarboxylase antizyme inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102458.1NP_001095928.1  antizyme inhibitor 1 isoform 1

    See identical proteins and their annotated locations for NP_001095928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC167019, AK049680, CF534695
    Consensus CDS
    CCDS37065.1
    UniProtKB/Swiss-Prot
    O35484, Q8K1E5
    Related
    ENSMUSP00000105958.2, ENSMUST00000110329.8
    Conserved Domains (1) summary
    cd06831
    Location:26419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
  2. NM_001301688.1NP_001288617.1  antizyme inhibitor 1 isoform 2

    See identical proteins and their annotated locations for NP_001288617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced in the 3' coding region, which causes a frame-shift, compared to variant 1. The resulting isoform (2) is shorter with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC167019, AK049680, BC046814, CD353412, CF738062, CF749918
    UniProtKB/Swiss-Prot
    O35484
    Conserved Domains (1) summary
    cl00261
    Location:26361
    PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
  3. NM_018745.5NP_061215.1  antizyme inhibitor 1 isoform 1

    See identical proteins and their annotated locations for NP_061215.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC167019, AK049680
    Consensus CDS
    CCDS37065.1
    UniProtKB/Swiss-Prot
    O35484, Q8K1E5
    Related
    ENSMUSP00000065544.6, ENSMUST00000065308.13
    Conserved Domains (1) summary
    cd06831
    Location:26419
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

RNA

  1. NR_125913.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as Azin1-X) lacks an exon in the 5' region and uses an alternate acceptor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a target for nonsense-mediated mRNA decay (NMD). The regulation of expression of this variant by polyamines is described in PMID:24077669.
    Source sequence(s)
    AC167019, AK049680, BC046814, CD353412
    Related
    ENSMUST00000129589.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    38487674..38523506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520114.5XP_006520177.1  antizyme inhibitor 1 isoform X1

    Conserved Domains (1) summary
    cd06831
    Location:26418
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
  2. XM_006520117.3XP_006520180.1  antizyme inhibitor 1 isoform X2

    Conserved Domains (1) summary
    cl00261
    Location:1252
    PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
  3. XM_030248661.2XP_030104521.1  antizyme inhibitor 1 isoform X1

    Conserved Domains (1) summary
    cd06831
    Location:26418
    PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
  4. XM_036159520.1XP_036015413.1  antizyme inhibitor 1 isoform X2

    Conserved Domains (1) summary
    cl00261
    Location:1252
    PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes