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POLD2 DNA polymerase delta 2, accessory subunit [ Homo sapiens (human) ]

Gene ID: 5425, updated on 24-Nov-2020

Summary

Official Symbol
POLD2provided by HGNC
Official Full Name
DNA polymerase delta 2, accessory subunitprovided by HGNC
Primary source
HGNC:HGNC:9176
See related
Ensembl:ENSG00000106628 MIM:600815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in heart (RPKM 20.0), ovary (RPKM 19.1) and 25 other tissues See more
Orthologs

Genomic context

See POLD2 in Genome Data Viewer
Location:
7p13
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44114680..44123668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44154279..44163267, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 6838 Neighboring gene DNA polymerase mu Neighboring gene AE binding protein 1 Neighboring gene microRNA 4649 Neighboring gene RNA, 5S ribosomal pseudogene 230 Neighboring gene myosin light chain 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
DNA replication TAS
Traceable Author Statement
more info
PubMed 
DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA gap filling TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision, 5'-to lesion TAS
Traceable Author Statement
more info
 
telomere maintenance TAS
Traceable Author Statement
more info
 
telomere maintenance via semi-conservative replication TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delta DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
zeta DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase delta subunit 2
Names
DAN polymerase delta 2, accessory subunit
DNA polymerase delta subunit p50
Pol delta B subunit (p50)
polymerase (DNA directed), delta 2, accessory subunit
polymerase (DNA directed), delta 2, regulatory subunit 50kDa
polymerase (DNA) delta 2, accessory subunit
NP_001120690.1
NP_001243808.1
NP_006221.3
XP_024302570.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127218.3NP_001120690.1  DNA polymerase delta subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_001120690.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK312294, AW732014, BC000459, BP224472
    Consensus CDS
    CCDS5477.1
    UniProtKB/Swiss-Prot
    P49005
    Related
    ENSP00000395231.1, ENST00000452185.5
    Conserved Domains (1) summary
    cd07387
    Location:215452
    MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
  2. NM_001256879.2NP_001243808.1  DNA polymerase delta subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_001243808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC006454, AK292347, AW732014, BC000459, DB025069
    Consensus CDS
    CCDS5477.1
    UniProtKB/Swiss-Prot
    P49005
    Related
    ENSP00000386105.2, ENST00000406581.6
    Conserved Domains (1) summary
    cd07387
    Location:215452
    MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
  3. NM_006230.4NP_006221.3  DNA polymerase delta subunit 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC006454
    Consensus CDS
    CCDS75586.1
    Related
    ENSP00000480186.1, ENST00000610533.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44114680..44123668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446802.1XP_024302570.1  DNA polymerase delta subunit 2 isoform X1

    Related
    ENSP00000223361.3, ENST00000223361.7
    Conserved Domains (1) summary
    cd07387
    Location:215452
    MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain

RNA

  1. XR_002956453.1 RNA Sequence

  2. XR_002956452.1 RNA Sequence

  3. XR_002956457.1 RNA Sequence

  4. XR_002956456.1 RNA Sequence

  5. XR_002956455.1 RNA Sequence

  6. XR_002956454.1 RNA Sequence

  7. XR_002956458.1 RNA Sequence

  8. XR_002956459.1 RNA Sequence

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