U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arl6ip1 ADP-ribosylation factor-like 6 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 54208, updated on 8-May-2024

Summary

Official Symbol
Arl6ip1provided by MGI
Official Full Name
ADP-ribosylation factor-like 6 interacting protein 1provided by MGI
Primary source
MGI:MGI:1858943
See related
Ensembl:ENSMUSG00000030654 AllianceGenome:MGI:1858943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIP-6; ARMER; Aip-1; Arl6ip; mKIAA0069
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of L-glutamate import across plasma membrane. Acts upstream of or within cotranslational protein targeting to membrane. Located in cytosol and endoplasmic reticulum. Is integral component of membrane. Part of Sec61 translocon complex. Is expressed in several structures, including central nervous system; genitourinary system; retina; and stomach. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 117.1), CNS E11.5 (RPKM 89.0) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Arl6ip1 in Genome Data Viewer
Location:
7 F1; 7 63.44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (117718113..117728848, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118118890..118129625, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34878 Neighboring gene STARR-positive B cell enhancer ABC_E1357 Neighboring gene ribosomal protein S15A Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:125272620-125272803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:125273191-125273420 Neighboring gene SMG1 nonsense mediated mRNA decay associated PI3K related kinase Neighboring gene predicted gene, 25683 Neighboring gene STARR-seq mESC enhancer starr_20001 Neighboring gene predicted gene, 40454

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Sec61 translocon complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 6-interacting protein 1
Names
ADP-ribosylation-like factor 6 interacting protein
ARL-6-interacting protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019419.2NP_062292.1  ADP-ribosylation factor-like protein 6-interacting protein 1

    See identical proteins and their annotated locations for NP_062292.1

    Status: VALIDATED

    Source sequence(s)
    AC131788, AK152565, BC046792
    Consensus CDS
    CCDS21769.1
    UniProtKB/Swiss-Prot
    Q9JKW0, Q9JLI9, Q9WUG3
    UniProtKB/TrEMBL
    Q3TIC7, Q80ZW9, Q8C1Y9
    Related
    ENSMUSP00000032888.8, ENSMUST00000032888.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    117718113..117728848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)