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Rnf5 ring finger protein 5 [ Mus musculus (house mouse) ]

Gene ID: 54197, updated on 30-Oct-2022

Summary

Official Symbol
Rnf5provided by MGI
Official Full Name
ring finger protein 5provided by MGI
Primary source
MGI:MGI:1860076
See related
Ensembl:ENSMUSG00000015478 AllianceGenome:MGI:1860076
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NG2; 2410131O05Rik
Summary
Predicted to enable identical protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Acts upstream of or within several processes, including negative regulation of autophagy; protein destabilization; and regulation of autophagosome assembly. Located in membrane. Is expressed in dorsal root ganglion; limb; neural tube; testis; and urinary system. Orthologous to human RNF5 (ring finger protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 88.4), large intestine adult (RPKM 73.5) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf5 in Genome Data Viewer
Location:
17 B1; 17 18.18 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34820073..34822535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34601099..34603561, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene pre B cell leukemia homeobox 2 Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) Neighboring gene EGF-like domain 8 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-like protein conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF5
Names
RING-type E3 ubiquitin transferase RNF5
NP_062276.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019403.3NP_062276.1  E3 ubiquitin-protein ligase RNF5

    See identical proteins and their annotated locations for NP_062276.1

    Status: PROVISIONAL

    Source sequence(s)
    CT009767
    Consensus CDS
    CCDS28650.1
    UniProtKB/Swiss-Prot
    O35445
    UniProtKB/TrEMBL
    A0A8C6MS08
    Related
    ENSMUSP00000015622.8, ENSMUST00000015622.8
    Conserved Domains (2) summary
    PLN03208
    Location:25117
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cd16743
    Location:2570
    RING-HC_RNF5; RING finger, HC subclass, found in RING finger protein 5 (RNF5) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34820073..34822535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)