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DCUN1D1 defective in cullin neddylation 1 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 54165, updated on 7-Oct-2018

Summary

Official Symbol
DCUN1D1provided by HGNC
Official Full Name
defective in cullin neddylation 1 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18184
See related
Ensembl:ENSG00000043093 MIM:605905; Vega:OTTHUMG00000158314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
Expression
Broad expression in testis (RPKM 16.2), bone marrow (RPKM 6.8) and 24 other tissues See more
Orthologs

Genomic context

See DCUN1D1 in Genome Data Viewer
Location:
3q26.33
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (182938158..182986364, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182660153..182703731, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374245 Neighboring gene ATPase phospholipid transporting 11B (putative) Neighboring gene eukaryotic translation initiation factor 3 subunit E pseudogene 4 Neighboring gene chromosome 9 open reading frame 85 pseudogene Neighboring gene uncharacterized LOC105374246 Neighboring gene methylcrotonoyl-CoA carboxylase 1 Neighboring gene uncharacterized LOC105374247

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of protein neddylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DCN1-like protein 1
Names
DCN1, defective in cullin neddylation 1, domain containing 1
DCUN1 domain-containing protein 1
RP42 homolog
defective in cullin neddylation protein 1-like protein 1
squamous cell carcinoma-related oncogene

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308101.1NP_001295030.1  DCN1-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001295030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC092953, AF292100, AK025764, AW103206, BC013163, BI828039, BU620603, HY052047
    Consensus CDS
    CCDS77862.1
    UniProtKB/Swiss-Prot
    Q96GG9
    UniProtKB/TrEMBL
    C9JVE2
    Related
    ENSP00000419359.1, OTTHUMP00000212784, ENST00000469954.5, OTTHUMT00000350659
    Conserved Domains (2) summary
    pfam03556
    Location:121231
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  2. NM_020640.3NP_065691.2  DCN1-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_065691.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC092953, AF292100, AK025764, AK297328, AW103206, BC013163, BU620603, HY031019
    Consensus CDS
    CCDS3240.1
    UniProtKB/Swiss-Prot
    Q96GG9
    UniProtKB/TrEMBL
    B4DM76
    Related
    ENSP00000292782.4, OTTHUMP00000212783, ENST00000292782.8, OTTHUMT00000350658
    Conserved Domains (2) summary
    pfam03556
    Location:136246
    Cullin_binding; Cullin binding
    cl21463
    Location:151
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    182938158..182986364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512915.2XP_011511217.1  DCN1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011511217.1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  2. XM_011512916.2XP_011511218.1  DCN1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011511218.1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  3. XM_011512914.1XP_011511216.1  DCN1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011511216.1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  4. XM_011512912.2XP_011511214.1  DCN1-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011511214.1

    Conserved Domains (2) summary
    pfam03556
    Location:136234
    Cullin_binding; Cullin binding
    cl21463
    Location:151
    UBA_like_SF; UBA domain-like superfamily
  5. XM_017006634.1XP_016862123.1  DCN1-like protein 1 isoform X1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  6. XM_017006633.1XP_016862122.1  DCN1-like protein 1 isoform X1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  7. XM_017006635.2XP_016862124.1  DCN1-like protein 1 isoform X3

    UniProtKB/TrEMBL
    C9JVE2
    Conserved Domains (2) summary
    pfam03556
    Location:121231
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  8. XM_024453601.1XP_024309369.1  DCN1-like protein 1 isoform X3

    Related
    ENSP00000488427.1, ENST00000632685.1
    Conserved Domains (2) summary
    pfam03556
    Location:121231
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
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