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FAM3B FAM3 metabolism regulating signaling molecule B [ Homo sapiens (human) ]

Gene ID: 54097, updated on 5-Jul-2020

Summary

Official Symbol
FAM3Bprovided by HGNC
Official Full Name
FAM3 metabolism regulating signaling molecule Bprovided by HGNC
Primary source
HGNC:HGNC:1253
See related
Ensembl:ENSG00000183844 MIM:608617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76
Expression
Biased expression in duodenum (RPKM 47.4), small intestine (RPKM 44.3) and 11 other tissues See more
Orthologs

Genomic context

See FAM3B in Genome Data Viewer
Location:
21q22.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (41304229..41357727)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (42688661..42729654)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene microRNA 3197 Neighboring gene beta-secretase 2 Neighboring gene placenta enriched 4 Neighboring gene MX dynamin like GTPase 2 Neighboring gene MX dynamin like GTPase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
NHGRI GWA Catalog
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
NHGRI GWA Catalog
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein FAM3B
Names
D21M16SJHU19e
cytokine-like protein 2-21
family with sequence similarity 3 member B
pancreatic derived factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058186.4NP_478066.3  protein FAM3B isoform a precursor

    See identical proteins and their annotated locations for NP_478066.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK125528, AY358459, BC057829, BF514643, BI712971
    Consensus CDS
    CCDS13671.1
    UniProtKB/Swiss-Prot
    P58499
    Related
    ENSP00000350673.2, ENST00000357985.7
    Conserved Domains (1) summary
    cl19122
    Location:59232
    PANDER_like; Domains similar to the Pancreatic-derived factor
  2. NM_206964.2NP_996847.1  protein FAM3B isoform b

    See identical proteins and their annotated locations for NP_996847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK125528, AY040086, AY358459, BF514643, BI712971
    Consensus CDS
    CCDS42930.1
    UniProtKB/Swiss-Prot
    P58499
    Related
    ENSP00000381642.3, ENST00000398647.7
    Conserved Domains (1) summary
    cl19122
    Location:11184
    PANDER_like; Domains similar to the Pancreatic-derived factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    41304229..41357727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529649.2XP_011527951.1  protein FAM3B isoform X2

    Conserved Domains (1) summary
    cl19122
    Location:73246
    PANDER_like; Domains similar to the Pancreatic-derived factor
  2. XM_011529648.2XP_011527950.2  protein FAM3B isoform X1

RNA

  1. XR_937526.2 RNA Sequence

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