FAM3B FAM3 metabolism regulating signaling molecule B [Homo sapiens (human)] - Gene

Summary

Official Symbol: FAM3Bprovided by HGNC
Official Full Name: FAM3 metabolism regulating signaling molecule Bprovided by HGNC
Primary source: HGNC:HGNC:1253
See related: Ensembl:ENSG00000183844 MIM:608617; AllianceGenome:HGNC:1253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 2-21; ORF9; PANDER; PRED44; C21orf11; C21orf76
Summary: Involved in insulin secretion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum (RPKM 47.4), small intestine (RPKM 44.3) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q22.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (41304242..41357727)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (39705395..39746338)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (42688728..42729654)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric Cancer by Inducing Epithelial-Mesenchymal Transition.
Title: Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric Cancer by Inducing Epithelial-Mesenchymal Transition.
Increased pancreatic-derived factor (PANDER) levels in gestational diabetes mellitus.
Title: Increased pancreatic-derived factor (PANDER) levels in gestational diabetes mellitus.
High FAM3B promotes progression of esophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition.
Title: FAM3B promotes progression of oesophageal carcinoma via regulating the AKT-MDM2-p53 signalling axis and the epithelial-mesenchymal transition.
Taken together, by activating pro-survival mechanisms FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice, highlighting a putative role for this cytokine in prostate cancer progression.
Title: FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.
FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice.
Title: FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-X(L) cell survival genes.
Data suggest that serum PANDER levels are significantly elevated in patients with long-standing type 2 diabetes as compared to patients with recently diagnosed type 2 diabetes and control subjects; serum PANDER levels vary according to degree of insulin resistance.
Title: Association of serum pancreatic derived factor (PANDER) with beta-cell dysfunction in type 2 diabetes mellitus.
Circulating level of pancreatic-derived factor (PANDER) in relation to the accumulation in metabolic syndrome suggested that persons with elevated levels of PANDER were associated with an increased risk of metabolic syndrome.
Title: Elevated circulating level of a cytokine, pancreatic-derived factor, is associated with metabolic syndrome components in a Chinese population.
in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP.
Title: Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter.
beta-cell-secreted PANDER regulated the hepatic insulin and lipogenenic signaling and impact overall glycemia.
Title: PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance.
It is an important regulator of glucose and lipid metabolism and plays a role in the pathogenesis of nonalcoholic fatty liver disease.(review)
Title: Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and &#x000ce;&#x000b1; fetoprotein and their associations with cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-52452 (e-PCR)
- UniSTS:82949

D21S1224 (e-PCR)
- UniSTS:42276

SHGC-132814 (e-PCR)
- UniSTS:170903

D21S64 (e-PCR)
- UniSTS:147891

Homology

Homologs of the FAM3B gene: The FAM3B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 336 organisms have orthologs with human gene FAM3B
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: protein FAM3B

Names: D21M16SJHU19e; cytokine-like protein 2-21; family with sequence similarity 3 member B; pancreatic derived factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_058186.4 → NP_478066.3 protein FAM3B isoform a precursor

See identical proteins and their annotated locations for NP_478066.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK125528, AY358459, BC057829, BF514643, BI712971

Consensus CDS

CCDS13671.1

UniProtKB/Swiss-Prot

P58499

Related

ENSP00000350673.2, ENST00000357985.7

Conserved Domains (1) summary

cl19122
Location:59 → 232

PANDER_like; Domains similar to the Pancreatic-derived factor
NM_206964.2 → NP_996847.1 protein FAM3B isoform b

See identical proteins and their annotated locations for NP_996847.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AK125528, AY040086, AY358459, BF514643, BI712971

Consensus CDS

CCDS42930.1

UniProtKB/Swiss-Prot

P58499

Related

ENSP00000381642.3, ENST00000398647.7

Conserved Domains (1) summary

cl19122
Location:11 → 184

PANDER_like; Domains similar to the Pancreatic-derived factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p14 Primary Assembly

Range

41304242..41357727

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011529649.3 → XP_011527951.1 protein FAM3B isoform X2

Conserved Domains (1) summary

cl19122
Location:73 → 246

PANDER_like; Domains similar to the Pancreatic-derived factor
XM_011529648.3 → XP_011527950.3 protein FAM3B isoform X1

Related

ENSP00000381641.3, ENST00000398646.3