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MIS18A MIS18 kinetochore protein A [ Homo sapiens (human) ]

Gene ID: 54069, updated on 17-Jun-2019

Summary

Official Symbol
MIS18Aprovided by HGNC
Official Full Name
MIS18 kinetochore protein Aprovided by HGNC
Primary source
HGNC:HGNC:1286
See related
Ensembl:ENSG00000159055 MIM:618137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B28; FASP1; C21orf45; C21orf46; MIS18alpha; hMis18alpha
Expression
Broad expression in testis (RPKM 8.3), bone marrow (RPKM 3.6) and 24 other tissues See more
Orthologs

Genomic context

See MIS18A in Genome Data Viewer
Location:
21q22.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (32154682..32283954, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33640530..33651376, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene hormonally up-regulated Neu-associated kinase Neighboring gene long intergenic non-protein coding RNA 159 Neighboring gene uncharacterized LOC105372779 Neighboring gene melanocortin 2 receptor accessory protein Neighboring gene URB1 ribosome biogenesis homolog Neighboring gene small nucleolar RNA, H/ACA box 80A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein Mis18-alpha
Names
FAPP1-associated protein 1
MIS18 kinetochore protein homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018944.3NP_061817.1  protein Mis18-alpha

    See identical proteins and their annotated locations for NP_061817.1

    Status: VALIDATED

    Source sequence(s)
    AK075281, AW962893, BU567844, BU616573, CB959520
    Consensus CDS
    CCDS13611.1
    UniProtKB/Swiss-Prot
    Q9NYP9
    Related
    ENSP00000290130.3, ENST00000290130.4
    Conserved Domains (1) summary
    pfam03226
    Location:81179
    Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    32154682..32283954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028402.1XP_016883891.1  protein Mis18-alpha isoform X3

  2. XM_017028400.1XP_016883889.1  protein Mis18-alpha isoform X1

  3. XM_017028401.1XP_016883890.1  protein Mis18-alpha isoform X2

RNA

  1. XR_002958619.1 RNA Sequence

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