TOPBP1 DNA topoisomerase II binding protein 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TOPBP1provided by VGNC
Official Full Name: DNA topoisomerase II binding protein 1provided by VGNC
Primary source: VGNC:VGNC:49585
See related: BGD:BT22685; Ensembl:ENSBTAG00000000526
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	1	NC_037328.1 (135753556..135824536)

Chromosome 1 - NC_037328.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA topoisomerase 2-binding protein 1

Names: topoisomerase (DNA) II binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206766.2 → NP_001193695.1 DNA topoisomerase 2-binding protein 1

See identical proteins and their annotated locations for NP_001193695.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000001

UniProtKB/TrEMBL

G3X684

Related

ENSBTAP00000067344.2, ENSBTAT00000084226.2

Conserved Domains (3) summary

smart00292
Location:356 → 431

BRCT; breast cancer carboxy-terminal domain

pfam00533
Location:105 → 176

BRCT; BRCA1 C Terminus (BRCT) domain

pfam12738
Location:203 → 266

PTCB-BRCT; twin BRCT domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

Range

135753556..135824536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005201960.5 → XP_005202017.1 DNA topoisomerase 2-binding protein 1 isoform X2

UniProtKB/TrEMBL

G3X684

Conserved Domains (3) summary

smart00292
Location:351 → 426

BRCT; breast cancer carboxy-terminal domain

pfam00533
Location:105 → 176

BRCT; BRCA1 C Terminus (BRCT) domain

pfam12738
Location:203 → 266

PTCB-BRCT; twin BRCT domain
XM_059886074.1 → XP_059742057.1 DNA topoisomerase 2-binding protein 1 isoform X1

Related

ENSBTAP00000059732.2, ENSBTAT00000078321.2
XM_059886079.1 → XP_059742062.1 DNA topoisomerase 2-binding protein 1 isoform X3