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RBM11 RNA binding motif protein 11 [ Homo sapiens (human) ]

Gene ID: 54033, updated on 23-Nov-2021

Summary

Official Symbol
RBM11provided by HGNC
Official Full Name
RNA binding motif protein 11provided by HGNC
Primary source
HGNC:HGNC:9897
See related
Ensembl:ENSG00000185272 MIM:617937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in ovary (RPKM 1.3), thyroid (RPKM 1.3) and 21 other tissues See more
Orthologs
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Genomic context

See RBM11 in Genome Data Viewer
Location:
21q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (14216107..14228372)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (15588478..15600693)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1456 Neighboring gene endoplasmic reticulum lectin 1 pseudogene 1 Neighboring gene lipase I Neighboring gene ATP binding cassette subfamily C member 13 (pseudogene) Neighboring gene heat shock protein family A (Hsp70) member 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
splicing regulator RBM11
Names
putative RNA-binding protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320602.2NP_001307531.1  splicing regulator RBM11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice acceptor site in the 3' coding region, compared to variant 1. This variant encodes a protein (isoform 2) with a longer C-terminus, compared to isoform 1.
    Source sequence(s)
    BC030196, CB153254, CN430785
    UniProtKB/Swiss-Prot
    P57052
    Conserved Domains (2) summary
    COG0724
    Location:5139
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12593
    Location:983
    RRM_RBM11; RNA recognition motif in vertebrate RNA-binding protein 11 (RBM11)
  2. NM_144770.5NP_658983.3  splicing regulator RBM11 isoform 1

    See identical proteins and their annotated locations for NP_658983.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC030196, CB153254
    Consensus CDS
    CCDS46635.1
    UniProtKB/Swiss-Prot
    P57052
    Related
    ENSP00000383421.3, ENST00000400577.4
    Conserved Domains (1) summary
    cd12593
    Location:983
    RRM_RBM11; RNA recognition motif in vertebrate RNA-binding protein 11 (RBM11)

RNA

  1. NR_135308.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF519623, BC030196, CB153254
    Related
    ENST00000495055.1
  2. NR_135309.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences at alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF519623, BC030196, CB153254, CN430785
  3. NR_135310.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK091331, BC030196, CB153254
    Related
    ENST00000468643.5
  4. NR_135311.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences at alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC030196, CN430785

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    14216107..14228372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260997.5XP_005261054.1  splicing regulator RBM11 isoform X1

    Conserved Domains (2) summary
    COG0724
    Location:5139
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12593
    Location:983
    RRM_RBM11; RNA recognition motif in vertebrate RNA-binding protein 11 (RBM11)
  2. XM_017028387.1XP_016883876.1  splicing regulator RBM11 isoform X3

    UniProtKB/Swiss-Prot
    P57052
    UniProtKB/TrEMBL
    D3DSC2
  3. XM_017028386.1XP_016883875.1  splicing regulator RBM11 isoform X3

    UniProtKB/Swiss-Prot
    P57052
    UniProtKB/TrEMBL
    D3DSC2
  4. XM_017028385.2XP_016883874.1  splicing regulator RBM11 isoform X3

    UniProtKB/Swiss-Prot
    P57052
    UniProtKB/TrEMBL
    D3DSC2
  5. XM_017028384.2XP_016883873.1  splicing regulator RBM11 isoform X2

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