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Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform [ Mus musculus (house mouse) ]

Gene ID: 53892, updated on 5-Mar-2024

Summary

Official Symbol
Ppm1dprovided by MGI
Official Full Name
protein phosphatase 1D magnesium-dependent, delta isoformprovided by MGI
Primary source
MGI:MGI:1858214
See related
Ensembl:ENSMUSG00000020525 AllianceGenome:MGI:1858214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wip1
Summary
Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Involved in DNA methylation and heterochromatin assembly. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and response to bacterium. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 45.8), cerebellum adult (RPKM 8.9) and 21 other tissues See more
Orthologs
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Genomic context

See Ppm1d in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85202080..85237897)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (85311254..85347071)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38935 Neighboring gene STARR-seq mESC enhancer starr_30238 Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene amyloid beta precursor protein binding protein 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30241 Neighboring gene STARR-positive B cell enhancer ABC_E593 Neighboring gene STARR-positive B cell enhancer ABC_E303 Neighboring gene BCAS3 microtubule associated cell migration factor Neighboring gene STARR-seq mESC enhancer starr_30248 Neighboring gene STARR-seq mESC enhancer starr_30251 Neighboring gene limb enhancer upstream of Tbx2 Neighboring gene STARR-seq mESC enhancer starr_30253 Neighboring gene BCAS3 microtubule associated cell migration factor, opposite strand 1 Neighboring gene microRNA 5110

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cation binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein phosphatase 1D
Names
PP2C-delta
p53-induced protein phosphatase 1
protein phosphatase magnesium-dependent 1 delta
NP_058606.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016910.3NP_058606.3  protein phosphatase 1D

    See identical proteins and their annotated locations for NP_058606.3

    Status: VALIDATED

    Source sequence(s)
    AK157818, AW488397, BC051966
    Consensus CDS
    CCDS25194.1
    UniProtKB/Swiss-Prot
    B1B0B0, Q9QZ67
    UniProtKB/TrEMBL
    Q80WV2, Q8R1N9
    Related
    ENSMUSP00000020835.10, ENSMUST00000020835.16
    Conserved Domains (1) summary
    pfam00481
    Location:84361
    PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    85202080..85237897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)