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Septin9 septin 9 [ Mus musculus (house mouse) ]

Gene ID: 53860, updated on 8-Jan-2023

Summary

Official Symbol
Septin9provided by MGI
Official Full Name
septin 9provided by MGI
Primary source
MGI:MGI:1858222
See related
Ensembl:ENSMUSG00000059248 AllianceGenome:MGI:1858222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msf; MSF1; Sept9; Sint1; PNUTL4
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization; cytoskeleton-dependent cytokinesis; and positive regulation of non-motile cilium assembly. Predicted to act upstream of or within cell division. Part of septin complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in brachial plexus neuritis. Orthologous to human SEPTIN9 (septin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 25.9), thymus adult (RPKM 24.2) and 28 other tissues See more
Orthologs
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Genomic context

See Septin9 in Genome Data Viewer
Location:
11 E2; 11 82.61 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117090487..117253151)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117199661..117362325)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 6516 Neighboring gene small nucleolar RNA host gene 20 Neighboring gene SEC14-like lipid binding 1 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene predicted gene, 39478 Neighboring gene VISTA enhancer mm1309 Neighboring gene predicted gene, 34065 Neighboring gene predicted gene, 34128 Neighboring gene predicted gene 11729

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of septin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
septin-9
Names
MLL septin-like fusion
SL3-3 integration site 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113486.1NP_001106958.1  septin-9 isoform a

    See identical proteins and their annotated locations for NP_001106958.1

    Status: VALIDATED

    Source sequence(s)
    AK122415, AK141312, AL645975, AW538697
    Consensus CDS
    CCDS48990.1
    UniProtKB/Swiss-Prot
    Q80UG5, Q9QYX9
    Related
    ENSMUSP00000091435.5, ENSMUST00000093907.11
    Conserved Domains (2) summary
    cd01850
    Location:293567
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:275580
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  2. NM_001113487.1NP_001106959.1  septin-9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AK122415, AW538697, BU148654
    Consensus CDS
    CCDS48991.1
    UniProtKB/Swiss-Prot
    Q80UG5
    Related
    ENSMUSP00000019038.9, ENSMUST00000019038.15
    Conserved Domains (2) summary
    cd01850
    Location:286560
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:268573
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  3. NM_001113488.1NP_001106960.1  septin-9 isoform c

    See identical proteins and their annotated locations for NP_001106960.1

    Status: VALIDATED

    Source sequence(s)
    AK031757, AK122415, AW538697, BY035742, BY772945
    Consensus CDS
    CCDS25684.1
    UniProtKB/Swiss-Prot
    Q80UG5
    UniProtKB/TrEMBL
    A0A8C6G4W0
    Related
    ENSMUSP00000101956.2, ENSMUST00000106349.2
    Conserved Domains (1) summary
    cd01850
    Location:44318
    CDC_Septin; CDC/Septin GTPase family
  4. NM_017380.2NP_059076.1  septin-9 isoform c

    See identical proteins and their annotated locations for NP_059076.1

    Status: VALIDATED

    Source sequence(s)
    AJ250723, AK031757, AW538697, BU612221
    Consensus CDS
    CCDS25684.1
    UniProtKB/Swiss-Prot
    Q80UG5
    UniProtKB/TrEMBL
    A0A8C6G4W0
    Related
    ENSMUSP00000097767.2, ENSMUST00000100193.8
    Conserved Domains (1) summary
    cd01850
    Location:44318
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117090487..117253151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533744.3XP_006533807.1  septin-9 isoform X1

    UniProtKB/TrEMBL
    A2A6U3
    Related
    ENSMUSP00000101961.3, ENSMUST00000106354.9
    Conserved Domains (2) summary
    cd01850
    Location:275549
    CDC_Septin; CDC/Septin GTPase family
    PHA03247
    Location:20214
    PHA03247; large tegument protein UL36; Provisional
  2. XM_006533746.5XP_006533809.1  septin-9 isoform X2

    See identical proteins and their annotated locations for XP_006533809.1

    UniProtKB/Swiss-Prot
    Q80UG5
    UniProtKB/TrEMBL
    A0A8C6G4W0
    Conserved Domains (1) summary
    cd01850
    Location:44318
    CDC_Septin; CDC/Septin GTPase family
  3. XM_030246153.2XP_030102013.1  septin-9 isoform X2

    UniProtKB/TrEMBL
    A0A8C6G4W0
    Conserved Domains (1) summary
    cd01850
    Location:44318
    CDC_Septin; CDC/Septin GTPase family
  4. XM_030246154.1XP_030102014.1  septin-9 isoform X2

    UniProtKB/TrEMBL
    A0A8C6G4W0
    Conserved Domains (1) summary
    cd01850
    Location:44318
    CDC_Septin; CDC/Septin GTPase family
  5. XM_006533745.5XP_006533808.2  septin-9 isoform X2

    See identical proteins and their annotated locations for XP_006533808.2

    UniProtKB/Swiss-Prot
    Q80UG5
    UniProtKB/TrEMBL
    A0A8C6G4W0
    Conserved Domains (1) summary
    cd01850
    Location:44318
    CDC_Septin; CDC/Septin GTPase family
  6. XM_036156849.1XP_036012742.1  septin-9 isoform X2

    UniProtKB/TrEMBL
    A0A8C6G4W0
    Conserved Domains (1) summary
    cd01850
    Location:44318
    CDC_Septin; CDC/Septin GTPase family