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GPR87 G protein-coupled receptor 87 [ Homo sapiens (human) ]

Gene ID: 53836, updated on 13-Mar-2020

Summary

Official Symbol
GPR87provided by HGNC
Official Full Name
G protein-coupled receptor 87provided by HGNC
Primary source
HGNC:HGNC:4538
See related
Ensembl:ENSG00000138271 MIM:606379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR95; FKSG78; KPG_002
Summary
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]
Expression
Biased expression in skin (RPKM 16.8), esophagus (RPKM 16.5) and 4 other tissues See more
Orthologs

Genomic context

See GPR87 in Genome Data Viewer
Location:
3q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151294086..151316820, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151011874..151034636, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene G protein-coupled receptor 171 Neighboring gene purinergic receptor P2Y14 Neighboring gene SET pseudogene 11 Neighboring gene purinergic receptor P2Y13 Neighboring gene purinergic receptor P2Y12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC131898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
negative regulation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein coupled receptor 87
Names
G-protein coupled receptor 95
orphan GPCR 87

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023915.4NP_076404.3  G-protein coupled receptor 87

    See identical proteins and their annotated locations for NP_076404.3

    Status: VALIDATED

    Source sequence(s)
    AF345566, BC117565, BP226924
    Consensus CDS
    CCDS3157.1
    UniProtKB/Swiss-Prot
    Q9BY21
    Related
    ENSP00000260843.4, ENST00000260843.5
    Conserved Domains (1) summary
    cd15969
    Location:43325
    7tmA_GPR87; G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151294086..151316820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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