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GPR84 G protein-coupled receptor 84 [ Homo sapiens (human) ]

Gene ID: 53831, updated on 23-Nov-2023

Summary

Official Symbol
GPR84provided by HGNC
Official Full Name
G protein-coupled receptor 84provided by HGNC
Primary source
HGNC:HGNC:4535
See related
Ensembl:ENSG00000139572 MIM:606383; AllianceGenome:HGNC:4535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EX33; GPCR4
Summary
Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 5.7), appendix (RPKM 3.3) and 6 other tissues See more
Orthologs
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Genomic context

See GPR84 in Genome Data Viewer
Location:
12q13.13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (54350698..54364486, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (54317281..54331118, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54756229..54758270, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene RNA, 7SL, cytoplasmic 744, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54750728-54751553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:54751554-54752378 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:54752379-54753203 Neighboring gene GPR84, ZNF385A, ITGA5 and GTSF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6441 Neighboring gene zinc finger protein 385A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:54781074-54781708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:54781709-54782342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4529 Neighboring gene integrin subunit alpha 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54805235-54806017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54806018-54806799

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables urotensin II receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G-protein coupled receptor 84
Names
inflammation-related G protein-coupled receptor EX33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020370.3NP_065103.1  G-protein coupled receptor 84

    See identical proteins and their annotated locations for NP_065103.1

    Status: VALIDATED

    Source sequence(s)
    BC020614, BP303386, CD366881
    Consensus CDS
    CCDS8878.1
    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9
    Related
    ENSP00000267015.3, ENST00000267015.4
    Conserved Domains (1) summary
    cd15210
    Location:21381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    54350698..54364486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429017.1XP_047284973.1  G-protein coupled receptor 84 isoform X2

    UniProtKB/TrEMBL
    A8K2X9
  2. XM_011538495.3XP_011536797.1  G-protein coupled receptor 84 isoform X1

    See identical proteins and their annotated locations for XP_011536797.1

    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9
    Conserved Domains (1) summary
    cd15210
    Location:21381
    7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    54317281..54331118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372309.1XP_054228284.1  G-protein coupled receptor 84 isoform X2

    UniProtKB/TrEMBL
    A8K2X9
  2. XM_054372308.1XP_054228283.1  G-protein coupled receptor 84 isoform X1

    UniProtKB/Swiss-Prot
    B6V9G7, Q9NQS5
    UniProtKB/TrEMBL
    A8K2X9