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Blcap bladder cancer associated protein [ Mus musculus (house mouse) ]

Gene ID: 53619, updated on 2-Nov-2024

Summary

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Official Symbol
Blcapprovided by MGI
Official Full Name
bladder cancer associated proteinprovided by MGI
Primary source
MGI:MGI:1858907
See related
Ensembl:ENSMUSG00000067787 AllianceGenome:MGI:1858907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bc10
Summary
Predicted to be involved in apoptotic nuclear changes. Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in brain and spinal cord. Orthologous to human BLCAP (BLCAP apoptosis inducing factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 60.0), CNS E18 (RPKM 57.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Blcap in Genome Data Viewer
Location:
2 H1; 2 78.4 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157398282..157408281, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157556362..157566361, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rous sarcoma oncogene Neighboring gene VISTA enhancer mm1673 Neighboring gene predicted gene 14279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:157392020-157392207 Neighboring gene neuronatin Neighboring gene STARR-seq mESC enhancer starr_06215 Neighboring gene pluripotency associated transcript 27 Neighboring gene STARR-seq mESC enhancer starr_06217 Neighboring gene predicted gene, 34293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers. John RM, et al. Dev Biol, 2001 Aug 15. PMID 11476579
  2. Transcript- and tissue-specific imprinting of a tumour suppressor gene. Schulz R, et al. Hum Mol Genet, 2009 Jan 1. PMID 18836209, Free PMC Article
  3. A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. Pfisterer P, et al. J Biol Chem, 2002 Feb 22. PMID 11741941
  4. ZFP57 dictates allelic expression switch of target imprinted genes. Jiang W, et al. Proc Natl Acad Sci U S A, 2021 Feb 2. PMID 33500348, Free PMC Article
  5. Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Ling KH, et al. Genome Biol, 2009. PMID 19799774, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blcap is imprinted in mouse and human brain, but not in other mouse tissues.
    Title: Transcript- and tissue-specific imprinting of a tumour suppressor gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC102074

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in apoptotic nuclear changes IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic nuclear changes ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apoptosis inducing factor BLCAP
Names
BLCAP apoptosis inducing factor
Blcapbladder cancer associated protein homolog
bladder cancer 10 kDa protein
bladder cancer associated protein homolog
bladder cancer related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355426.1 → NP_001342355.1  apoptosis inducing factor BLCAP

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL672259
    Consensus CDS
    CCDS16979.1
    UniProtKB/Swiss-Prot
    A2AFZ4, P62951, Q3TD76, Q5XJG3
    Related
    ENSMUSP00000085849.3, ENSMUST00000088494.3
    Conserved Domains (1) summary
    pfam06726
    Location:1 → 65
    BC10; Bladder cancer-related protein BC10

  2. NM_016916.3 → NP_058612.3  apoptosis inducing factor BLCAP

    See identical proteins and their annotated locations for NP_058612.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC083339, BM950751, BY718283
    Consensus CDS
    CCDS16979.1
    UniProtKB/Swiss-Prot
    A2AFZ4, P62951, Q3TD76, Q5XJG3
    Related
    ENSMUSP00000105154.3, ENSMUST00000109528.9
    Conserved Domains (1) summary
    pfam06726
    Location:1 → 65
    BC10; Bladder cancer-related protein BC10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157398282..157408281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62951.1 GenPept UniProtKB/Swiss-Prot:P62951

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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