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Vti1a vesicle transport through interaction with t-SNAREs 1A [ Mus musculus (house mouse) ]

Gene ID: 53611, updated on 13-Dec-2022

Summary

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Official Symbol
Vti1aprovided by MGI
Official Full Name
vesicle transport through interaction with t-SNAREs 1Aprovided by MGI
Primary source
MGI:MGI:1855699
See related
Ensembl:ENSMUSG00000024983 AllianceGenome:MGI:1855699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vti1; MVti1; MVti1a; Vti1-rp2; 1110014F16Rik; 1110018K19Rik; 4921537J05Rik
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; endosomal transport; and voluntary musculoskeletal movement. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including autophagosome; cytoplasmic vesicle; and neuronal cell body. Predicted to be part of SNARE complex. Predicted to be active in Golgi apparatus; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human VTI1A (vesicle transport through interaction with t-SNAREs 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Vti1a in Genome Data Viewer
Location:
19; 19 D2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55304489..55615893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55316030..55627461)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31595 Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene zinc finger, DHHC domain containing 6 Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene predicted gene, 41871 Neighboring gene predicted gene, 31734 Neighboring gene transcription factor 7 like 2, T cell specific, HMG box

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28γ knockout in HCV pathogenesis: a network-based study. Tripathi LP, et al. J Proteome Res, 2012 Jul 6. PMID 22646850
  2. Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development. Bollmann C, et al. Neural Dev, 2022 Nov 22. PMID 36419086, Free PMC Article
  3. The SNARE protein vti1a functions in dense-core vesicle biogenesis. Walter AM, et al. EMBO J, 2014 Aug 1. PMID 24902738, Free PMC Article
  4. SNAREs in neurons--beyond synaptic vesicle exocytosis (Review). Wang Y, et al. Mol Membr Biol, 2006 Sep-Oct. PMID 17060155
  5. A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. Xu Y, et al. J Biol Chem, 1998 Aug 21. PMID 9705316

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
    Title: Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
  2. Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
    Title: Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
  3. In adrenal chromaffin cells, vti1a localizes to a compartment near the trans-Golgi-network, but is absent from secretory granules.Vti1a is not required for final fusion of dense-core vesicles, but is needed for their generation.
    Title: The SNARE protein vti1a functions in dense-core vesicle biogenesis.
  4. VTI1A, a vesicular transport associated factor is a novel regulator of hepatitis C virus release but not replication.
    Title: Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28γ knockout in HCV pathogenesis: a network-based study.
  5. Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development
    Title: Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102006

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle to endosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in vesicle fusion with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in voluntary musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vesicle transport through interaction with t-SNAREs homolog 1A
Names
vesicle transport through interaction with t-SNAREs 1 homolog
vesicle transport v-SNARE protein Vti1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293685.1 → NP_001280614.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 1

    See identical proteins and their annotated locations for NP_001280614.1

    Status: VALIDATED

    Source sequence(s)
    AC133100, BB767664, BC089321
    Consensus CDS
    CCDS89416.1
    UniProtKB/TrEMBL
    A0A8C6IL44, Q5FWJ7
    Related
    ENSMUSP00000153629.2, ENSMUST00000223690.2
    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  2. NM_001293686.1 → NP_001280615.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK028646, AK148281, BB767664, BC089321
    UniProtKB/Swiss-Prot
    O89116
    UniProtKB/TrEMBL
    A0A6P5P2V7, Q5FWJ7
    Conserved Domains (2) summary
    cd15891
    Location:122 → 183
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 89
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  3. NM_001360431.1 → NP_001347360.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC133100, AC166100, CO430297
    UniProtKB/TrEMBL
    A0A6P7QHG3
    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  4. NM_001360432.1 → NP_001347361.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK135463
    Consensus CDS
    CCDS89417.1
    UniProtKB/TrEMBL
    A0A286YDF2
    Related
    ENSMUSP00000153392.2, ENSMUST00000225529.2
    Conserved Domains (2) summary
    cd15891
    Location:122 → 183
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  5. NM_016862.4 → NP_058558.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform 2

    See identical proteins and their annotated locations for NP_058558.1

    Status: VALIDATED

    Source sequence(s)
    AC133100, AK028646, BB767664, BC089321
    Consensus CDS
    CCDS29910.1
    UniProtKB/Swiss-Prot
    O89116, Q545P9
    UniProtKB/TrEMBL
    Q5FWJ7
    Related
    ENSMUSP00000093644.3, ENSMUST00000095950.3
    Conserved Domains (2) summary
    cd15891
    Location:122 → 183
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55304489..55615893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161635.1 → XP_036017528.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X12

    Conserved Domains (2) summary
    pfam05008
    Location:12 → 89
    V-SNARE; Vesicle transport v-SNARE protein N-terminus
    cl22856
    Location:122 → 142
    SNARE; SNARE motif

  2. XM_036161636.1 → XP_036017529.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X14

    Conserved Domains (2) summary
    pfam05008
    Location:12 → 89
    V-SNARE; Vesicle transport v-SNARE protein N-terminus
    cl22856
    Location:122 → 142
    SNARE; SNARE motif

  3. XM_017318251.3 → XP_017173740.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X3

    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  4. XM_030250990.2 → XP_030106850.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X4

    Conserved Domains (2) summary
    cd15891
    Location:122 → 183
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  5. XM_006527192.5 → XP_006527255.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X9

    See identical proteins and their annotated locations for XP_006527255.1

    UniProtKB/TrEMBL
    A0A6P7QHG3
    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  6. XM_006527191.4 → XP_006527254.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X8

    See identical proteins and their annotated locations for XP_006527254.1

    UniProtKB/TrEMBL
    A0A6P7QHG3
    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  7. XM_006527188.4 → XP_006527251.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X7

    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  8. XM_036161633.1 → XP_036017526.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X10

    UniProtKB/TrEMBL
    A0A6P5P2V7
    Conserved Domains (2) summary
    cd15891
    Location:122 → 183
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 89
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  9. XM_036161630.1 → XP_036017523.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X5

    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 89
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  10. XM_036161631.1 → XP_036017524.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X6

    Conserved Domains (2) summary
    cd15891
    Location:122 → 183
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 89
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  11. XM_006527184.5 → XP_006527247.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X1

    Conserved Domains (2) summary
    cd15891
    Location:129 → 190
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  12. XM_006527185.5 → XP_006527248.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X2

    Conserved Domains (2) summary
    cd15891
    Location:122 → 183
    SNARE_Vti1a; SNARE motif of Vti1b-like
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  13. XM_036161634.1 → XP_036017527.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X11

    Conserved Domains (2) summary
    pfam05008
    Location:12 → 89
    V-SNARE; Vesicle transport v-SNARE protein N-terminus
    cl22856
    Location:129 → 149
    SNARE; SNARE motif

  14. XM_006527198.5 → XP_006527261.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X15

    Conserved Domains (1) summary
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus

  15. XM_006527196.5 → XP_006527259.1  vesicle transport through interaction with t-SNAREs homolog 1A isoform X13

    Conserved Domains (2) summary
    pfam05008
    Location:12 → 90
    V-SNARE; Vesicle transport v-SNARE protein N-terminus
    cl22856
    Location:129 → 149
    SNARE; SNARE motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89116.1 GenPept UniProtKB/Swiss-Prot:O89116

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