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Gnpat Glyceronephosphate O-acyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 53586, updated on 11-Sep-2024

Summary

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Official Symbol
Gnpatprovided by FlyBase
Official Full Name
Glyceronephosphate O-acyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0040212
Locus tag
Dmel_CG4625
See related
AllianceGenome:FB:FBgn0040212
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
8-1; CG4625; Dhap-at; DHAP-AT; DHAPAT; Dmel\CG4625; GNPAT; Gpat; GPAT
Summary
Predicted to enable glycerone-phosphate O-acyltransferase activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to be located in peroxisomal membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
96E2-96E2; 3-88 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25485618..25490936, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21311340..21316658, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene XNP Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44179 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Santoro C, et al. Sci Rep, 2022 Jul 29. PMID 35906462, Free PMC Article
  2. Ecdysone and insulin signaling play essential roles in readjusting the altered body size caused by the dGPAT4 mutation in Drosophila. Yan Y, et al. J Genet Genomics, 2015 Sep 20. PMID 26408093
  3. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Seegmiller AC, et al. Dev Cell, 2002 Feb. PMID 11832248
  4. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Kim GH, et al. Biochem Biophys Res Commun, 2015 Jan 9. PMID 25511696
  5. Conditioned courtship suppression in Drosophila melanogaster. Raun N, et al. J Neurogenet, 2021 Sep. PMID 33522326

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerone-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerone-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ether lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ether lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ether lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
glyceronephosphate O-acyltransferase
Names
CG4625-PA
CG4625-PB
CG4625-PC
Gnpat-PA
Gnpat-PB
Gnpat-PC
dihydroxyacetone phosphate acyltansferase
dihydroxyacetone phosphate acyltransferase
glycerol 3-phosphate acyltransferase
glycerol-3-phosphate acyltransferase
glycerol-3-phosphate-acyltransferase
NP_001262956.1
NP_001262957.1
NP_525010.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25485618..25490936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080271.4 → NP_525010.1  glyceronephosphate O-acyltransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525010.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHF2, Q9VBQ6
    Related
    FBpp0084271
    Conserved Domains (1) summary
    cd07993
    Location:133 → 338
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  2. NM_001276028.1 → NP_001262957.1  glyceronephosphate O-acyltransferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262957.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHK0, Q9NHF2
    Conserved Domains (1) summary
    cd07993
    Location:133 → 338
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  3. NM_001276027.1 → NP_001262956.1  glyceronephosphate O-acyltransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262956.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHF2, Q9VBQ6
    Conserved Domains (1) summary
    cd07993
    Location:133 → 338
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHK0 A0A0B4KHK0
Q95RN8 Q95RN8
Q9NHF2 Q9NHF2
Q9VBQ6 Q9VBQ6

Gene LinkOut

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