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PLGLB1 plasminogen like B1 [ Homo sapiens (human) ]

Gene ID: 5343, updated on 17-Sep-2024

Summary

Official Symbol
PLGLB1provided by HGNC
Official Full Name
plasminogen like B1provided by HGNC
Primary source
HGNC:HGNC:9072
See related
Ensembl:ENSG00000183281 MIM:173340; AllianceGenome:HGNC:9072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLGL; PRGB; PLGP1; PRP-B
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver (RPKM 64.1) and skin (RPKM 1.9) See more
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Genomic context

See PLGLB1 in Genome Data Viewer
Location:
2p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (87010224..87021844, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (87015434..87027063, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87237347..87248967, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RANBP2 like and GRIP domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:87169373-87170136 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 5 Neighboring gene WBP1 pseudogene 1 Neighboring gene ANAPC1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11725 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:87303801-87304306 Neighboring gene tRNA-Pro (anticodon AGG) 4-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
plasminogen-like protein B
Names
plasminogen-related protein B
type B plasminogen related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032392.4NP_001027564.1  plasminogen-like protein B precursor

    See identical proteins and their annotated locations for NP_001027564.1

    Status: VALIDATED

    Source sequence(s)
    AC111200, AC125232
    Consensus CDS
    CCDS33238.1
    UniProtKB/Swiss-Prot
    Q02325, Q15195, Q580R1
    Related
    ENSP00000347933.3, ENST00000355705.4
    Conserved Domains (1) summary
    cd01099
    Location:2296
    PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    87010224..87021844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    87015434..87027063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)