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Prdx4 peroxiredoxin 4 [ Mus musculus (house mouse) ]

Gene ID: 53381, updated on 31-Jan-2019

Summary

Official Symbol
Prdx4provided by MGI
Official Full Name
peroxiredoxin 4provided by MGI
Primary source
MGI:MGI:1859815
See related
Ensembl:ENSMUSG00000025289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prx4; TRANK; AOE372; Prx-iv
Expression
Ubiquitous expression in liver E18 (RPKM 59.9), placenta adult (RPKM 58.8) and 28 other tissues See more
Orthologs

Genomic context

See Prdx4 in Genome Data Viewer
Location:
X F3; X 72.38 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (155323918..155340749, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (151758463..151772997, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene Neighboring gene acyl-CoA thioesterase 9 Neighboring gene predicted gene, 39545 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
4-hydroxyproline metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell redox homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of male germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation by protein folding IGI
Inferred from Genetic Interaction
more info
PubMed 
reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-4
Names
Prx IV
antioxidant enzyme AOE372
peroxiredoxin IV
thioredoxin peroxidase AO372
thioredoxin-dependent peroxide reductase A0372
NP_001300640.1
NP_058044.1
XP_011246146.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313711.1NP_001300640.1  peroxiredoxin-4 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK152255, AW121558, CJ079814
    UniProtKB/Swiss-Prot
    O08807
    Conserved Domains (2) summary
    cd03015
    Location:84254
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    pfam00578
    Location:84217
    AhpC-TSA; AhpC/TSA family
  2. NM_016764.5NP_058044.1  peroxiredoxin-4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_058044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks contains an alternate exon in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK152255, AW121558, CJ079814
    Consensus CDS
    CCDS30496.1
    UniProtKB/Swiss-Prot
    O08807
    Related
    ENSMUSP00000026328.4, ENSMUST00000026328.10
    Conserved Domains (2) summary
    COG0450
    Location:84272
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:84255
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    155323918..155340749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247844.1XP_011246146.1  peroxiredoxin-4 isoform X1

    Related
    ENSMUSP00000122997.1, ENSMUST00000130349.2
    Conserved Domains (3) summary
    COG0450
    Location:65255
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:67238
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    pfam15304
    Location:660
    AKAP2_C; A-kinase anchor protein 2 C-terminus
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