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Prdx4 peroxiredoxin 4 [ Mus musculus (house mouse) ]

Gene ID: 53381, updated on 29-Nov-2022

Summary

Official Symbol
Prdx4provided by MGI
Official Full Name
peroxiredoxin 4provided by MGI
Primary source
MGI:MGI:1859815
See related
Ensembl:ENSMUSG00000025289 AllianceGenome:MGI:1859815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prx4; TRANK; AOE372; Prx-iv
Summary
Enables identical protein binding activity. Acts upstream of or within several processes, including cell redox homeostasis; negative regulation of male germ cell proliferation; and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Located in cytosol and endoplasmic reticulum. Is expressed in dorsal root ganglion; embryo; future spinal cord; and spinal cord. Orthologous to human PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 59.9), placenta adult (RPKM 58.8) and 28 other tissues See more
Orthologs
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Genomic context

See Prdx4 in Genome Data Viewer
Location:
X F3; X 72.38 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (154106914..154125268, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (155323918..155342272, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene Neighboring gene acyl-CoA thioesterase 9 Neighboring gene predicted gene, 39545 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-4
Names
Prx IV
antioxidant enzyme AOE372
peroxiredoxin IV
thioredoxin peroxidase AO372
thioredoxin-dependent peroxide reductase A0372
thioredoxin-dependent peroxiredoxin 4
NP_001300640.1
NP_058044.1
XP_011246146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313711.1NP_001300640.1  peroxiredoxin-4 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK152255, AW121558, CJ079814
    UniProtKB/Swiss-Prot
    O08807
    Conserved Domains (2) summary
    cd03015
    Location:84254
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    pfam00578
    Location:84217
    AhpC-TSA; AhpC/TSA family
  2. NM_016764.5NP_058044.1  peroxiredoxin-4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_058044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks contains an alternate exon in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK152255, AW121558, CJ079814
    Consensus CDS
    CCDS30496.1
    UniProtKB/Swiss-Prot
    O08807, Q3U8E4
    Related
    ENSMUSP00000026328.5, ENSMUST00000026328.11
    Conserved Domains (2) summary
    COG0450
    Location:84272
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:84255
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    154106914..154125268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247844.2XP_011246146.1  peroxiredoxin-4 isoform X1

    Related
    ENSMUSP00000122997.2, ENSMUST00000130349.3
    Conserved Domains (1) summary
    cd03015
    Location:67238
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...