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Sdcbp syndecan binding protein [ Mus musculus (house mouse) ]

Gene ID: 53378, updated on 17-Nov-2020

Summary

Official Symbol
Sdcbpprovided by MGI
Official Full Name
syndecan binding proteinprovided by MGI
Primary source
MGI:MGI:1337026
See related
Ensembl:ENSMUSG00000028249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sy; syn; MDA-; Sycl; MDA-9; synte; syntenin-1
Expression
Ubiquitous expression in placenta adult (RPKM 62.3), bladder adult (RPKM 56.4) and 28 other tissues See more
Orthologs

Genomic context

See Sdcbp in Genome Data Viewer
Location:
4; 4 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (6365654..6396122)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (6365680..6396122)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (6292827..6323269)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Cyp7a1 promoter Neighboring gene cytochrome P450, family 7, subfamily a, polypeptide 1 Neighboring gene RIKEN cDNA 4930430E12 gene Neighboring gene neutral sphingomyelinase (N-SMase) activation associated factor Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
frizzled binding ISO
Inferred from Sequence Orthology
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-5 receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
syndecan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syndecan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Ras protein signal transduction IPI
Inferred from Physical Interaction
more info
PubMed 
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extracellular exosome assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
interleukin-5 receptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
syntenin-1
Names
scaffold protein Pbp1
syndecan interacting protein
syndecan-binding protein 1
syntenin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098227.1NP_001091697.1  syntenin-1 isoform 1

    See identical proteins and their annotated locations for NP_001091697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK150278, BB736053, BY387130, BY757323, BY779386, W65143
    Consensus CDS
    CCDS51110.1
    UniProtKB/Swiss-Prot
    O08992
    Related
    ENSMUSP00000029912.4, ENSMUST00000029912.10
    Conserved Domains (1) summary
    cd00992
    Location:113192
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_016807.2NP_058087.2  syntenin-1 isoform 2

    See identical proteins and their annotated locations for NP_058087.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK150278, BB736053, BY387130, BY757323, BY779386, W65143
    Consensus CDS
    CCDS17951.1
    UniProtKB/Swiss-Prot
    O08992
    UniProtKB/TrEMBL
    Q3TMX0
    Related
    ENSMUSP00000100073.5, ENSMUST00000103008.11
    Conserved Domains (1) summary
    cd00992
    Location:112191
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    6365654..6396122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164236.1XP_036020129.1  syntenin-1 isoform X1

    Conserved Domains (1) summary
    cd00992
    Location:113192
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_036164237.1XP_036020130.1  syntenin-1 isoform X2

    Conserved Domains (1) summary
    cd00992
    Location:112191
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_006538084.5XP_006538147.1  syntenin-1 isoform X1

    See identical proteins and their annotated locations for XP_006538147.1

    UniProtKB/Swiss-Prot
    O08992
    Related
    ENSMUSP00000135777.1
    Conserved Domains (1) summary
    cd00992
    Location:113192
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_030253672.2XP_030109532.1  syntenin-1 isoform X2

    Conserved Domains (1) summary
    cd00992
    Location:112191
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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