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NUDT9 nudix hydrolase 9 [ Homo sapiens (human) ]

Gene ID: 53343, updated on 3-Apr-2024

Summary

Official Symbol
NUDT9provided by HGNC
Official Full Name
nudix hydrolase 9provided by HGNC
Primary source
HGNC:HGNC:8056
See related
Ensembl:ENSG00000170502 MIM:606022; AllianceGenome:HGNC:8056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUDT10
Summary
The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in kidney (RPKM 6.8), prostate (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

See NUDT9 in Genome Data Viewer
Location:
4q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (87422573..87459455)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (90749045..90788493)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88343725..88380607)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:88312635-88313207 Neighboring gene RNA, 7SL, cytoplasmic 681, pseudogene Neighboring gene mitochondrial ribosomal protein L19 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21707 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:88343613-88344547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:88345091-88345594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:88345595-88346096 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene SPARC like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:88432037-88432537 Neighboring gene uncharacterized LOC124900729 Neighboring gene NANOG hESC enhancer GRCh37_chr4:88441567-88442068

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
ADP-ribose pyrophosphatase, mitochondrial
Names
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
ADP-ribose pyrosphosphatase NUDT9
ADPR-PPase
adenosine diphosphoribose pyrophosphatase
nucleoside diphosphate linked moiety X-type motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
NP_001234940.1
NP_076952.1
NP_932155.1
XP_011530334.1
XP_054206165.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030358.1 RefSeqGene

    Range
    4998..41880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001248011.2NP_001234940.1  ADP-ribose pyrophosphatase, mitochondrial isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (c) missing an internal protein segment compared to isoform a.
    Source sequence(s)
    AC112250, AK027295, AK074845, AK308028, BP277630
    UniProtKB/TrEMBL
    Q96KB3
    Related
    ENSP00000410270.2, ENST00000440591.6
    Conserved Domains (1) summary
    cd03670
    Location:117303
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
  2. NM_024047.5NP_076952.1  ADP-ribose pyrophosphatase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_076952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as NUDT9 alpha) represents the predominant transcript, and encodes the longest isoform (a). This isoform is localized in the mitochondria (PMID:12427752).
    Source sequence(s)
    AC112250, AK027295, AK074845, BP277630
    Consensus CDS
    CCDS3620.1
    UniProtKB/Swiss-Prot
    Q8NBN1, Q8NCB9, Q8NG25, Q9BW91
    UniProtKB/TrEMBL
    Q96KB3
    Related
    ENSP00000303575.4, ENST00000302174.9
    Conserved Domains (1) summary
    cd03670
    Location:149335
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
  3. NM_198038.3NP_932155.1  ADP-ribose pyrophosphatase, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_932155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as NUDT9 beta) contains an alternatively spliced 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (b) with a shorter N-terminus compared to isoform a. This isoform lacks the signal peptide and is not targeted to the mitochondria (PMID:12427752).
    Source sequence(s)
    AC112250, AF265341, AK074845
    Consensus CDS
    CCDS3621.1
    UniProtKB/TrEMBL
    Q8NG26
    Related
    ENSP00000421811.1, ENST00000473942.5
    Conserved Domains (1) summary
    cd03670
    Location:99285
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    87422573..87459455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532032.3XP_011530334.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011530334.1

    UniProtKB/TrEMBL
    Q8NG26
    Conserved Domains (1) summary
    cd03670
    Location:99285
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

RNA

  1. XR_007057928.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    90749045..90788493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350190.1XP_054206165.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

RNA

  1. XR_008486993.1 RNA Sequence