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NUDT9 nudix hydrolase 9 [ Homo sapiens (human) ]

Gene ID: 53343, updated on 7-Dec-2018

Summary

Official Symbol
NUDT9provided by HGNC
Official Full Name
nudix hydrolase 9provided by HGNC
Primary source
HGNC:HGNC:8056
See related
Ensembl:ENSG00000170502 MIM:606022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUDT10
Summary
The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in kidney (RPKM 6.8), prostate (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See NUDT9 in Genome Data Viewer
Location:
4q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (87420002..87459454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88343728..88380606)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 11 Neighboring gene RNA, 7SL, cytoplasmic 681, pseudogene Neighboring gene mitochondrial ribosomal protein L19 pseudogene Neighboring gene uncharacterized LOC105377321 Neighboring gene SPARC like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3037

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribose diphosphatase activity EXP
Inferred from Experiment
more info
PubMed 
ADP-sugar diphosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
adenosine-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ADP catabolic process IEA
Inferred from Electronic Annotation
more info
 
IDP catabolic process IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ADP-ribose pyrophosphatase, mitochondrial
Names
ADP-ribose diphosphatase
ADP-ribose phosphohydrolase
ADP-ribose pyrosphosphatase NUDT9
ADPR-PPase
adenosine diphosphoribose pyrophosphatase
nucleoside diphosphate linked moiety X-type motif 9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
NP_001234940.1
NP_076952.1
NP_932155.1
XP_011530334.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030358.1 RefSeqGene

    Range
    5001..41879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001248011.1NP_001234940.1  ADP-ribose pyrophosphatase, mitochondrial isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (c) missing an internal protein segment compared to isoform a.
    Source sequence(s)
    AC112250, AK027295, AK074845, AK308028, BP277630
    UniProtKB/Swiss-Prot
    Q9BW91
    UniProtKB/TrEMBL
    Q96KB3
    Related
    ENSP00000410270.2, ENST00000440591.6
    Conserved Domains (1) summary
    cd03670
    Location:117303
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
  2. NM_024047.5NP_076952.1  ADP-ribose pyrophosphatase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_076952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as NUDT9 alpha) represents the predominant transcript, and encodes the longest isoform (a). This isoform is localized in the mitochondria (PMID:12427752).
    Source sequence(s)
    AC112250, AK027295, AK074845, BP277630
    Consensus CDS
    CCDS3620.1
    UniProtKB/Swiss-Prot
    Q9BW91
    UniProtKB/TrEMBL
    A0A024RDI6, Q96KB3
    Related
    ENSP00000303575.4, ENST00000302174.8
    Conserved Domains (1) summary
    cd03670
    Location:149335
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...
  3. NM_198038.2NP_932155.1  ADP-ribose pyrophosphatase, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_932155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as NUDT9 beta) contains an alternatively spliced 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (b) with a shorter N-terminus compared to isoform a. This isoform lacks the signal peptide and is not targeted to the mitochondria (PMID:12427752).
    Source sequence(s)
    AC112250, AF265341, AK074845
    Consensus CDS
    CCDS3621.1
    UniProtKB/Swiss-Prot
    Q9BW91
    UniProtKB/TrEMBL
    Q8NG26
    Related
    ENSP00000421811.1, ENST00000473942.5
    Conserved Domains (1) summary
    cd03670
    Location:99285
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    87420002..87459454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532032.2XP_011530334.1  ADP-ribose pyrophosphatase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011530334.1

    UniProtKB/Swiss-Prot
    Q9BW91
    Conserved Domains (1) summary
    cd03670
    Location:99285
    ADPRase_NUDT9; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. Like other members of the Nudix hydrolase superfamily of enzymes, it is thought to require a divalent cation, such as Mg2+, for its activity. It also ...

RNA

  1. XR_002959734.1 RNA Sequence

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