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Sco1 SCO1 cytochrome c oxidase assembly protein [ Mus musculus (house mouse) ]

Gene ID: 52892, updated on 12-May-2024

Summary

Official Symbol
Sco1provided by MGI
Official Full Name
SCO1 cytochrome c oxidase assembly proteinprovided by MGI
Primary source
MGI:MGI:106362
See related
Ensembl:ENSMUSG00000069844 AllianceGenome:MGI:106362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Bwg1310e; 2610001C07Rik
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including cyclooxygenase pathway; mitochondrial cytochrome c oxidase assembly; and negative regulation of protein kinase B signaling. Located in mitochondrion. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; submandibular gland primordium; and vascular element. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human SCO1 (synthesis of cytochrome C oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 3.2), colon adult (RPKM 2.8) and 28 other tissues See more
Orthologs
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Genomic context

See Sco1 in Genome Data Viewer
Location:
11 B3; 11 40.59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66943473..66958270)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67052600..67067444)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12299 Neighboring gene STARR-seq mESC enhancer starr_29788 Neighboring gene STARR-seq mESC enhancer starr_29789 Neighboring gene STARR-seq mESC enhancer starr_29791 Neighboring gene transmembrane protein 220 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene STARR-seq mESC enhancer starr_29794 Neighboring gene myosin, heavy polypeptide 3, skeletal muscle, embryonic Neighboring gene microRNA 6923 Neighboring gene RIKEN cDNA 2310065F04 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cyclooxygenase pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
protein SCO1 homolog, mitochondrial
Names
SCO cytochrome oxidase deficient homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040026.1NP_001035115.1  protein SCO1 homolog, mitochondrial

    See identical proteins and their annotated locations for NP_001035115.1

    Status: VALIDATED

    Source sequence(s)
    AK011251, AK018523, AK083729, AK139512
    Consensus CDS
    CCDS36183.1
    UniProtKB/Swiss-Prot
    Q3UTD6, Q5SUC9
    UniProtKB/TrEMBL
    Q5SUD5
    Related
    ENSMUSP00000090673.5, ENSMUST00000092996.5
    Conserved Domains (1) summary
    cd02968
    Location:119261
    SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    66943473..66958270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533721.3XP_006533784.1  protein SCO1 homolog, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd02968
    Location:25167
    SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...